Interaction between prenatal pesticide exposure and a common polymorphism in the PON1 gene on DNA methylation in genes associated with cardio-metabolic disease risk—an exploratory study

Interaction between prenatal pesticide exposure and a common polymorphism in the PON1 gene on DNA methylation in genes associated with cardio-metabolic disease risk—an exploratory study

Abstract Background Prenatal environmental conditions may influence disease risk in later life. We previously found a gene-environment interaction between the paraoxonase 1 (PON1) Q192R genotype and prenatal pesticide exposure leading to an adverse cardio-metabolic risk profile at school age. Howeve...

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Bibliographic Details
Main Authors: Ken Declerck, Sylvie Remy, Christine Wohlfahrt-Veje, Katharina M. Main, Guy Van Camp, Greet Schoeters, Wim Vanden Berghe, Helle R. Andersen
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Clinical Epigenetics
Subjects:
DNA methylation
Prenatal pesticide exposure
Paraoxonase 1
PON1 Q192R genotype
Illumina 450 K methylation array
Cardio-metabolic health
Online Access:http://link.springer.com/article/10.1186/s13148-017-0336-4

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