The worsening effect of anemia on left ventricular function and global strain in type 2 diabetes mellitus patients: a 3.0 T CMR feature tracking study
Abstract Objective To explore the additive effects of anemia on left ventricular (LV) global strains in patients with type 2 diabetes mellitus (T2DM) with or without anemia via cardiac magnetic resonance (CMR) feature tracking technology. Materials and methods 236 T2DM patients with or without anemi...
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12933-023-01745-3 |
| _version_ | 1811175997836361728 |
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| author | Wen-Lei Qian Rong Xu Rui Shi Yuan Li Ying-Kun Guo Han Fang Li jiang Zhi-Gang Yang |
| author_facet | Wen-Lei Qian Rong Xu Rui Shi Yuan Li Ying-Kun Guo Han Fang Li jiang Zhi-Gang Yang |
| author_sort | Wen-Lei Qian |
| collection | DOAJ |
| description | Abstract Objective To explore the additive effects of anemia on left ventricular (LV) global strains in patients with type 2 diabetes mellitus (T2DM) with or without anemia via cardiac magnetic resonance (CMR) feature tracking technology. Materials and methods 236 T2DM patients with or without anemia and 67 controls who underwent CMR examination were retrospectively enrolled. LV function parameters, LV global radial peak strain (GRPS), longitudinal peak strain (GLPS), and circumferential peak strain (GCPS) were used to analyze the function and global strain of the heart. One-way analysis of variance and the chi-square test were used for intergroup analysis. Multivariable linear regression analysis was performed for the two T2DM groups to explore factors associated with LV global strains. Results The T2DM group with anemia was oldest and had a lowest hemoglobin (Hb) concentration, lowest estimated glomerular filtration rate, highest LV end-systolic volume index, highest end-diastolic volume index and highest LV mass index than the control group and T2DM without anemia group (all P ≤ 0.001). Besides, The LV global peak strains in all three directions worsened successively from the control group to the T2DM without anemia group to the T2DM with anemia group (all p < 0.001). Among all clinical indices, the decrease in Hb was independently associated with the worsening in GRPS (β = 0.237, p = 0.001), GCPS (β = 0.326, p < 0.001), and GLPS (β = 0.265, p < 0.001). Conclusion Anemia has additive deleterious effects on LV function and LV global strains in patients with T2DM. Regular detection and early intervention of anemia might be beneficial for T2DM patients. |
| first_indexed | 2024-04-10T19:44:49Z |
| format | Article |
| id | doaj.art-023552dae39441e3afd82fd34cc8aa32 |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-04-10T19:44:49Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-023552dae39441e3afd82fd34cc8aa322023-01-29T12:03:41ZengBMCCardiovascular Diabetology1475-28402023-01-0122111010.1186/s12933-023-01745-3The worsening effect of anemia on left ventricular function and global strain in type 2 diabetes mellitus patients: a 3.0 T CMR feature tracking studyWen-Lei Qian0Rong Xu1Rui Shi2Yuan Li3Ying-Kun Guo4Han Fang5Li jiang6Zhi-Gang Yang7Department of Radiology, West China Hospital, Sichuan UniversityDepartment of Radiology, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan UniversityDepartment of Radiology, West China Hospital, Sichuan UniversityDepartment of Radiology, West China Hospital, Sichuan UniversityDepartment of Radiology, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan UniversityDepartment of Radiology, West China Hospital, Sichuan UniversityDepartment of Radiology, West China Hospital, Sichuan UniversityDepartment of Radiology, West China Hospital, Sichuan UniversityAbstract Objective To explore the additive effects of anemia on left ventricular (LV) global strains in patients with type 2 diabetes mellitus (T2DM) with or without anemia via cardiac magnetic resonance (CMR) feature tracking technology. Materials and methods 236 T2DM patients with or without anemia and 67 controls who underwent CMR examination were retrospectively enrolled. LV function parameters, LV global radial peak strain (GRPS), longitudinal peak strain (GLPS), and circumferential peak strain (GCPS) were used to analyze the function and global strain of the heart. One-way analysis of variance and the chi-square test were used for intergroup analysis. Multivariable linear regression analysis was performed for the two T2DM groups to explore factors associated with LV global strains. Results The T2DM group with anemia was oldest and had a lowest hemoglobin (Hb) concentration, lowest estimated glomerular filtration rate, highest LV end-systolic volume index, highest end-diastolic volume index and highest LV mass index than the control group and T2DM without anemia group (all P ≤ 0.001). Besides, The LV global peak strains in all three directions worsened successively from the control group to the T2DM without anemia group to the T2DM with anemia group (all p < 0.001). Among all clinical indices, the decrease in Hb was independently associated with the worsening in GRPS (β = 0.237, p = 0.001), GCPS (β = 0.326, p < 0.001), and GLPS (β = 0.265, p < 0.001). Conclusion Anemia has additive deleterious effects on LV function and LV global strains in patients with T2DM. Regular detection and early intervention of anemia might be beneficial for T2DM patients.https://doi.org/10.1186/s12933-023-01745-3Type 2 diabetes mellitusAnemiaHemoglobinCardiac magnetic resonanceFeature trackingLeft ventricular function |
| spellingShingle | Wen-Lei Qian Rong Xu Rui Shi Yuan Li Ying-Kun Guo Han Fang Li jiang Zhi-Gang Yang The worsening effect of anemia on left ventricular function and global strain in type 2 diabetes mellitus patients: a 3.0 T CMR feature tracking study Cardiovascular Diabetology Type 2 diabetes mellitus Anemia Hemoglobin Cardiac magnetic resonance Feature tracking Left ventricular function |
| title | The worsening effect of anemia on left ventricular function and global strain in type 2 diabetes mellitus patients: a 3.0 T CMR feature tracking study |
| title_full | The worsening effect of anemia on left ventricular function and global strain in type 2 diabetes mellitus patients: a 3.0 T CMR feature tracking study |
| title_fullStr | The worsening effect of anemia on left ventricular function and global strain in type 2 diabetes mellitus patients: a 3.0 T CMR feature tracking study |
| title_full_unstemmed | The worsening effect of anemia on left ventricular function and global strain in type 2 diabetes mellitus patients: a 3.0 T CMR feature tracking study |
| title_short | The worsening effect of anemia on left ventricular function and global strain in type 2 diabetes mellitus patients: a 3.0 T CMR feature tracking study |
| title_sort | worsening effect of anemia on left ventricular function and global strain in type 2 diabetes mellitus patients a 3 0 t cmr feature tracking study |
| topic | Type 2 diabetes mellitus Anemia Hemoglobin Cardiac magnetic resonance Feature tracking Left ventricular function |
| url | https://doi.org/10.1186/s12933-023-01745-3 |
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