Imbalanced and Unchecked: The Role of Metal Dyshomeostasis in Driving COPD Progression
AbstractChronic obstructive pulmonary disease (COPD) is a chronic respiratory condition characterized by persistent inflammation and oxidative stress, which ultimately leads to progressive restriction of airflow. Extensive research findings have cogently suggested that the dysregulation of essential...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | COPD |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/15412555.2024.2322605 |
| _version_ | 1797216608339361792 |
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| author | Ye Cui Xinqian Du Yunqi Li Dan Wang Zhe Lv Huihui Yuan Yan Chen Jie Liu Ying Sun Wei Wang |
| author_facet | Ye Cui Xinqian Du Yunqi Li Dan Wang Zhe Lv Huihui Yuan Yan Chen Jie Liu Ying Sun Wei Wang |
| author_sort | Ye Cui |
| collection | DOAJ |
| description | AbstractChronic obstructive pulmonary disease (COPD) is a chronic respiratory condition characterized by persistent inflammation and oxidative stress, which ultimately leads to progressive restriction of airflow. Extensive research findings have cogently suggested that the dysregulation of essential transition metal ions, notably iron, copper, and zinc, stands as a critical nexus in the perpetuation of inflammatory processes and oxidative damage within the lungs of COPD patients. Unraveling the intricate interplay between metal homeostasis, oxidative stress, and inflammatory signaling is of paramount importance in unraveling the intricacies of COPD pathogenesis. This comprehensive review aims to examine the current literature on the sources, regulation, and mechanisms by which metal dyshomeostasis contributes to COPD progression. We specifically focus on iron, copper, and zinc, given their well-characterized roles in orchestrating cytokine production, immune cell function, antioxidant depletion, and matrix remodeling. Despite the limited number of clinical trials investigating metal modulation in COPD, the advent of emerging methodologies tailored to monitor metal fluxes and gauge responses to chelation and supplementation hold great promise in unlocking the potential of metal-based interventions. We conclude that targeted restoration of metal homeostasis represents a promising frontier for ameliorating pathological processes driving COPD progression. |
| first_indexed | 2024-04-24T11:48:40Z |
| format | Article |
| id | doaj.art-0238bab151fd473b89156d942a9bb527 |
| institution | Directory Open Access Journal |
| issn | 1541-2555 1541-2563 |
| language | English |
| last_indexed | 2024-04-24T11:48:40Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | COPD |
| spelling | doaj.art-0238bab151fd473b89156d942a9bb5272024-04-09T08:25:56ZengTaylor & Francis GroupCOPD1541-25551541-25632024-12-0121110.1080/15412555.2024.2322605Imbalanced and Unchecked: The Role of Metal Dyshomeostasis in Driving COPD ProgressionYe Cui0Xinqian Du1Yunqi Li2Dan Wang3Zhe Lv4Huihui Yuan5Yan Chen6Jie Liu7Ying Sun8Wei Wang9Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, People’s Republic of ChinaDepartment of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, People’s Republic of ChinaDepartment of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, People’s Republic of ChinaDepartment of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, People’s Republic of ChinaDepartment of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, People’s Republic of ChinaDepartment of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, People’s Republic of ChinaDepartment of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, People’s Republic of ChinaDepartment of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, People’s Republic of ChinaDepartment of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, People’s Republic of ChinaDepartment of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, People’s Republic of ChinaAbstractChronic obstructive pulmonary disease (COPD) is a chronic respiratory condition characterized by persistent inflammation and oxidative stress, which ultimately leads to progressive restriction of airflow. Extensive research findings have cogently suggested that the dysregulation of essential transition metal ions, notably iron, copper, and zinc, stands as a critical nexus in the perpetuation of inflammatory processes and oxidative damage within the lungs of COPD patients. Unraveling the intricate interplay between metal homeostasis, oxidative stress, and inflammatory signaling is of paramount importance in unraveling the intricacies of COPD pathogenesis. This comprehensive review aims to examine the current literature on the sources, regulation, and mechanisms by which metal dyshomeostasis contributes to COPD progression. We specifically focus on iron, copper, and zinc, given their well-characterized roles in orchestrating cytokine production, immune cell function, antioxidant depletion, and matrix remodeling. Despite the limited number of clinical trials investigating metal modulation in COPD, the advent of emerging methodologies tailored to monitor metal fluxes and gauge responses to chelation and supplementation hold great promise in unlocking the potential of metal-based interventions. We conclude that targeted restoration of metal homeostasis represents a promising frontier for ameliorating pathological processes driving COPD progression.https://www.tandfonline.com/doi/10.1080/15412555.2024.2322605Ironcopperzincinflammationoxidative damagelung |
| spellingShingle | Ye Cui Xinqian Du Yunqi Li Dan Wang Zhe Lv Huihui Yuan Yan Chen Jie Liu Ying Sun Wei Wang Imbalanced and Unchecked: The Role of Metal Dyshomeostasis in Driving COPD Progression COPD Iron copper zinc inflammation oxidative damage lung |
| title | Imbalanced and Unchecked: The Role of Metal Dyshomeostasis in Driving COPD Progression |
| title_full | Imbalanced and Unchecked: The Role of Metal Dyshomeostasis in Driving COPD Progression |
| title_fullStr | Imbalanced and Unchecked: The Role of Metal Dyshomeostasis in Driving COPD Progression |
| title_full_unstemmed | Imbalanced and Unchecked: The Role of Metal Dyshomeostasis in Driving COPD Progression |
| title_short | Imbalanced and Unchecked: The Role of Metal Dyshomeostasis in Driving COPD Progression |
| title_sort | imbalanced and unchecked the role of metal dyshomeostasis in driving copd progression |
| topic | Iron copper zinc inflammation oxidative damage lung |
| url | https://www.tandfonline.com/doi/10.1080/15412555.2024.2322605 |
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