Endometrial Cancer Staging: Is There Value in ADC?
Purpose: To assess the ability of apparent diffusion coefficient (ADC) measurements in predicting the histological grade of endometrial cancer. A secondary goal was to assess the agreement between MRI and surgical staging as an accurate measurement. Methods: Patients with endometrial cancers diagnos...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/13/5/728 |
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| author | Ana Sofia Linhares Moreira Vera Ribeiro Giacomo Aringhieri Salvatore Claudio Fanni Lorenzo Tumminello Lorenzo Faggioni Dania Cioni Emanuele Neri |
| author_facet | Ana Sofia Linhares Moreira Vera Ribeiro Giacomo Aringhieri Salvatore Claudio Fanni Lorenzo Tumminello Lorenzo Faggioni Dania Cioni Emanuele Neri |
| author_sort | Ana Sofia Linhares Moreira |
| collection | DOAJ |
| description | Purpose: To assess the ability of apparent diffusion coefficient (ADC) measurements in predicting the histological grade of endometrial cancer. A secondary goal was to assess the agreement between MRI and surgical staging as an accurate measurement. Methods: Patients with endometrial cancers diagnosed between 2018–2020 and having received both MRI and surgical staging were retrospectively enrolled. Patients were characterized according to histology, tumor size, FIGO stage (MRI and surgical stage), and functional MRI parameters (DCE and DWI/ADC). Statistical analysis was performed to determine if an association could be identified between ADC variables and histology grade. Secondarily, we assessed the degree of agreement between the MRI and surgical stages according to the FIGO classification. Results: The cohort included 45 women with endometrial cancer. Quantitative analysis of ADC variables did not find a statistically significant association with histological tumor grades. DCE showed higher sensitivity than DWI/ADC in the assessment of myometrial invasion (85.00% versus 65.00%) with the same specificity (80.00%). A good agreement between MRI and histopathology for the FIGO stage was found (kappa of 0.72, <i>p</i> < 0.01). Differences in staging between MRI and surgery were detected in eight cases, which could not be justified by the interval between MRI and surgery. Conclusions. ADC values were not useful for predicting endometrial cancer grade, despite the good agreement between MRI interpretation and histopathology of endometrial cancer staging at our center. |
| first_indexed | 2024-03-11T03:35:02Z |
| format | Article |
| id | doaj.art-023961ff515a4158b5fbb93a7b981057 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-11T03:35:02Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-023961ff515a4158b5fbb93a7b9810572023-11-18T02:03:16ZengMDPI AGJournal of Personalized Medicine2075-44262023-04-0113572810.3390/jpm13050728Endometrial Cancer Staging: Is There Value in ADC?Ana Sofia Linhares Moreira0Vera Ribeiro1Giacomo Aringhieri2Salvatore Claudio Fanni3Lorenzo Tumminello4Lorenzo Faggioni5Dania Cioni6Emanuele Neri7Radiology Department, Centro Hospitalar Universitário do Algarve, 8000-386 Faro, PortugalGynaecology Department, Centro Hospitalar Universitário do Algarve, 8000-386 Faro, PortugalAcademic Radiology, Department of Translational Research, University of Pisa, 56126 Pisa, ItalyAcademic Radiology, Department of Translational Research, University of Pisa, 56126 Pisa, ItalyAcademic Radiology, Department of Translational Research, University of Pisa, 56126 Pisa, ItalyAcademic Radiology, Department of Translational Research, University of Pisa, 56126 Pisa, ItalyAcademic Radiology, Department of Translational Research, University of Pisa, 56126 Pisa, ItalyAcademic Radiology, Department of Translational Research, University of Pisa, 56126 Pisa, ItalyPurpose: To assess the ability of apparent diffusion coefficient (ADC) measurements in predicting the histological grade of endometrial cancer. A secondary goal was to assess the agreement between MRI and surgical staging as an accurate measurement. Methods: Patients with endometrial cancers diagnosed between 2018–2020 and having received both MRI and surgical staging were retrospectively enrolled. Patients were characterized according to histology, tumor size, FIGO stage (MRI and surgical stage), and functional MRI parameters (DCE and DWI/ADC). Statistical analysis was performed to determine if an association could be identified between ADC variables and histology grade. Secondarily, we assessed the degree of agreement between the MRI and surgical stages according to the FIGO classification. Results: The cohort included 45 women with endometrial cancer. Quantitative analysis of ADC variables did not find a statistically significant association with histological tumor grades. DCE showed higher sensitivity than DWI/ADC in the assessment of myometrial invasion (85.00% versus 65.00%) with the same specificity (80.00%). A good agreement between MRI and histopathology for the FIGO stage was found (kappa of 0.72, <i>p</i> < 0.01). Differences in staging between MRI and surgery were detected in eight cases, which could not be justified by the interval between MRI and surgery. Conclusions. ADC values were not useful for predicting endometrial cancer grade, despite the good agreement between MRI interpretation and histopathology of endometrial cancer staging at our center.https://www.mdpi.com/2075-4426/13/5/728endometrial cancermagnetic resonance imagingdiffusion-weighted imagingapparent diffusion coefficientdynamic contrast-enhanced magnetic resonance imagingstaging |
| spellingShingle | Ana Sofia Linhares Moreira Vera Ribeiro Giacomo Aringhieri Salvatore Claudio Fanni Lorenzo Tumminello Lorenzo Faggioni Dania Cioni Emanuele Neri Endometrial Cancer Staging: Is There Value in ADC? Journal of Personalized Medicine endometrial cancer magnetic resonance imaging diffusion-weighted imaging apparent diffusion coefficient dynamic contrast-enhanced magnetic resonance imaging staging |
| title | Endometrial Cancer Staging: Is There Value in ADC? |
| title_full | Endometrial Cancer Staging: Is There Value in ADC? |
| title_fullStr | Endometrial Cancer Staging: Is There Value in ADC? |
| title_full_unstemmed | Endometrial Cancer Staging: Is There Value in ADC? |
| title_short | Endometrial Cancer Staging: Is There Value in ADC? |
| title_sort | endometrial cancer staging is there value in adc |
| topic | endometrial cancer magnetic resonance imaging diffusion-weighted imaging apparent diffusion coefficient dynamic contrast-enhanced magnetic resonance imaging staging |
| url | https://www.mdpi.com/2075-4426/13/5/728 |
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