MDCK-Adaptive Mutation of A169S Changes Glycosylation Pattern of Hemagglutinin and Enhances MDCK-Based H7N9 Vaccine Virus Production without Loss of Antigenicity and Immunogenicity

MDCK-Adaptive Mutation of A169S Changes Glycosylation Pattern of Hemagglutinin and Enhances MDCK-Based H7N9 Vaccine Virus Production without Loss of Antigenicity and Immunogenicity

The adaptation of egg-derived H7N9 candidate vaccine virus (CVV) in the mammalian cell line is an approach to developing a high-growth virus strain for the mass production of vaccine manufacturing. The adaptive mutations that occur in hemagglutinin (HA) are critical to the activity and potency of th...

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Bibliographic Details
Main Authors: Po-Ling Chen, Tsai-Chuan Weng, Chia-Chun Lai, Tsai-Teng Tzeng, Min-Han Lin, Kai-Chieh Hu, Alan Yung-Chih Hu, Min-Shi Lee, Wang-Chou Sung
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Vaccines
Subjects:
H7N9
candidate vaccine virus
MDCK
adaptive mutation
glycosylation
Online Access:https://www.mdpi.com/2076-393X/12/3/291

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