Genome-wide analyses in Lyme borreliosis: identification of a genetic variant associated with disease susceptibility and its immunological implications

Genome-wide analyses in Lyme borreliosis: identification of a genetic variant associated with disease susceptibility and its immunological implications

Abstract Background Genetic variation underly inter-individual variation in host immune responses to infectious diseases, and may affect susceptibility or the course of signs and symptoms. Methods We performed genome-wide association studies in a prospective cohort of 1138 patients with physician-co...

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Bibliographic Details
Main Authors: Hedwig D. Vrijmoeth, Jeanine Ursinus, Javier Botey-Bataller, Yunus Kuijpers, Xiaojing Chu, Freek R. van de Schoor, Brendon P. Scicluna, Cheng-Jian Xu, Mihai G. Netea, Bart Jan Kullberg, Cees C. van den Wijngaard, Yang Li, Joppe W. Hovius, Leo A. B. Joosten
Format: Article
Language:English
Published: BMC 2024-03-01
Series:BMC Infectious Diseases
Subjects:
Lyme borreliosis
Disease susceptibility
GWAS
Cytokines
mTOR pathway
Online Access:https://doi.org/10.1186/s12879-024-09217-z

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