Consensus guidelines on the construct validity of rodent models of restless legs syndrome

Consensus guidelines on the construct validity of rodent models of restless legs syndrome

Our understanding of the causes and natural course of restless legs syndrome (RLS) is incomplete. The lack of objective diagnostic biomarkers remains a challenge for clinical research and for the development of valid animal models. As a task force of preclinical and clinical scientists, we have prev...

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Bibliographic Details
Main Authors: Aaro V. Salminen, Stefan Clemens, Diego García-Borreguero, Imad Ghorayeb, Yuqing Li, Mauro Manconi, William Ondo, David Rye, Jerome M. Siegel, Alessandro Silvani, John W. Winkelman, Richard P. Allen, Sergi Ferré, the International Restless Legs Syndrome Study Group (IRLSSG)
Format: Article
Language:English
Published: The Company of Biologists 2022-08-01
Series:Disease Models & Mechanisms
Subjects:
restless legs syndrome
rodent models
construct validity
guidelines
Online Access:http://dmm.biologists.org/content/15/8/dmm049615

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