Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury

Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury

Abstract Type 1 interferons (IFN) protect the host against viruses by engaging a cognate receptor (consisting of IFNAR1/IFNAR2 chains) and inducing downstream signaling and gene expression. However, inflammatory stimuli can trigger IFNAR1 ubiquitination and downregulation thereby attenuating IFN eff...

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Bibliographic Details
Main Authors: Sabyasachi Bhattacharya, Kanstantsin V Katlinski, Maximilian Reichert, Shigetsugu Takano, Angela Brice, Bin Zhao, Qiujing Yu, Hui Zheng, Christopher J Carbone, Yuliya V Katlinskaya, N Adrian Leu, Kelly A McCorkell, Satish Srinivasan, Melanie Girondo, Hallgeir Rui, Michael J May, Narayan G Avadhani, Anil K Rustgi, Serge Y Fuchs
Format: Article
Language:English
Published: Springer Nature 2014-03-01
Series:EMBO Molecular Medicine
Subjects:
hepatitis
inflammation
interferon
pancreatitis
receptor
Online Access:https://doi.org/10.1002/emmm.201303236

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