Young patients with colorectal cancer have poor survival in the first twenty months after operation and predictable survival in the medium and long-term: Analysis of survival and prognostic markers
<p>Abstract</p> <p>Objectives</p> <p>This study compares clinico-pathological features in young (<40 years) and older patients (>50 years) with colorectal cancer, survival in the young and the influence of pre-operative clinical and histological factors on surviva...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-09-01
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| Series: | World Journal of Surgical Oncology |
| Online Access: | http://www.wjso.com/content/8/1/82 |
| _version_ | 1818756062457626624 |
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| author | Wickramarachchi RE Deen R Dassanayake B Chan KK Kumarage SK Samita S Deen KI |
| author_facet | Wickramarachchi RE Deen R Dassanayake B Chan KK Kumarage SK Samita S Deen KI |
| author_sort | Wickramarachchi RE |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Objectives</p> <p>This study compares clinico-pathological features in young (<40 years) and older patients (>50 years) with colorectal cancer, survival in the young and the influence of pre-operative clinical and histological factors on survival.</p> <p>Materials and methods</p> <p>A twelve year prospective database of colorectal cancer was analysed. Fifty-three young patients were compared with forty seven consecutive older patients over fifty years old. An analysis of survival was undertaken in young patients using Kaplan Meier graphs, non parametric methods, Cox's Proportional Hazard Ratios and Weibull Hazard models.</p> <p>Results</p> <p>Young patients comprised 13.4 percent of 397 with colorectal cancer. Duration of symptoms and presentation in the young was similar to older patients (median, range; young patients; 6 months, 2 weeks to 2 years, older patients; 4 months, 4 weeks to 3 years, p > 0.05). In both groups, the majority presented without bowel obstruction (young - 81%, older - 94%). Cancer proximal to the splenic flexure was present more in young than in older patients. Synchronous cancers were found exclusively in the young. Mucinous tumours were seen in 16% of young and 4% of older patients (p < 0.05). Ninety four percent of young cancer deaths were within 20 months of operation. At median follow up of 50 months in the young, overall survival was 70% and disease free survival 66%. American Joint Committee on Cancer (AJCC) stage 4 and use of pre-operative chemoradiation in rectal cancer was associated with poor survival in the young.</p> <p>Conclusion</p> <p>If patients, who are less than 40 years old with colorectal cancer, survive twenty months after operation, the prognosis improves and their survival becomes predictable.</p> |
| first_indexed | 2024-12-18T05:49:04Z |
| format | Article |
| id | doaj.art-02422ae0c53c4cb1a61c4a0e9df12b2d |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-18T05:49:04Z |
| publishDate | 2010-09-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-02422ae0c53c4cb1a61c4a0e9df12b2d2022-12-21T21:18:58ZengBMCWorld Journal of Surgical Oncology1477-78192010-09-01818210.1186/1477-7819-8-82Young patients with colorectal cancer have poor survival in the first twenty months after operation and predictable survival in the medium and long-term: Analysis of survival and prognostic markersWickramarachchi REDeen RDassanayake BChan KKKumarage SKSamita SDeen KI<p>Abstract</p> <p>Objectives</p> <p>This study compares clinico-pathological features in young (<40 years) and older patients (>50 years) with colorectal cancer, survival in the young and the influence of pre-operative clinical and histological factors on survival.</p> <p>Materials and methods</p> <p>A twelve year prospective database of colorectal cancer was analysed. Fifty-three young patients were compared with forty seven consecutive older patients over fifty years old. An analysis of survival was undertaken in young patients using Kaplan Meier graphs, non parametric methods, Cox's Proportional Hazard Ratios and Weibull Hazard models.</p> <p>Results</p> <p>Young patients comprised 13.4 percent of 397 with colorectal cancer. Duration of symptoms and presentation in the young was similar to older patients (median, range; young patients; 6 months, 2 weeks to 2 years, older patients; 4 months, 4 weeks to 3 years, p > 0.05). In both groups, the majority presented without bowel obstruction (young - 81%, older - 94%). Cancer proximal to the splenic flexure was present more in young than in older patients. Synchronous cancers were found exclusively in the young. Mucinous tumours were seen in 16% of young and 4% of older patients (p < 0.05). Ninety four percent of young cancer deaths were within 20 months of operation. At median follow up of 50 months in the young, overall survival was 70% and disease free survival 66%. American Joint Committee on Cancer (AJCC) stage 4 and use of pre-operative chemoradiation in rectal cancer was associated with poor survival in the young.</p> <p>Conclusion</p> <p>If patients, who are less than 40 years old with colorectal cancer, survive twenty months after operation, the prognosis improves and their survival becomes predictable.</p>http://www.wjso.com/content/8/1/82 |
| spellingShingle | Wickramarachchi RE Deen R Dassanayake B Chan KK Kumarage SK Samita S Deen KI Young patients with colorectal cancer have poor survival in the first twenty months after operation and predictable survival in the medium and long-term: Analysis of survival and prognostic markers World Journal of Surgical Oncology |
| title | Young patients with colorectal cancer have poor survival in the first twenty months after operation and predictable survival in the medium and long-term: Analysis of survival and prognostic markers |
| title_full | Young patients with colorectal cancer have poor survival in the first twenty months after operation and predictable survival in the medium and long-term: Analysis of survival and prognostic markers |
| title_fullStr | Young patients with colorectal cancer have poor survival in the first twenty months after operation and predictable survival in the medium and long-term: Analysis of survival and prognostic markers |
| title_full_unstemmed | Young patients with colorectal cancer have poor survival in the first twenty months after operation and predictable survival in the medium and long-term: Analysis of survival and prognostic markers |
| title_short | Young patients with colorectal cancer have poor survival in the first twenty months after operation and predictable survival in the medium and long-term: Analysis of survival and prognostic markers |
| title_sort | young patients with colorectal cancer have poor survival in the first twenty months after operation and predictable survival in the medium and long term analysis of survival and prognostic markers |
| url | http://www.wjso.com/content/8/1/82 |
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