Effect of Antibiotic Compared to Non-Antibiotic Dry Cow Treatment on the Bacteriological Cure of Intramammary Infections during the Dry Period—A Retrospective Cross-Sectional Study
Antimicrobials are widely used to cure intramammary infections (IMI) in dairy cows during the dry period (DP). Nevertheless, the IMI cure is influenced by many factors and not all quarters benefit from antimicrobial dry cow treatment (DCT). To evaluate the true effect of antibiotic DCT compared to s...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/12/3/429 |
| _version_ | 1797613825257635840 |
|---|---|
| author | Stephanie Müller Julia Nitz Anne Tellen Doris Klocke Volker Krömker |
| author_facet | Stephanie Müller Julia Nitz Anne Tellen Doris Klocke Volker Krömker |
| author_sort | Stephanie Müller |
| collection | DOAJ |
| description | Antimicrobials are widely used to cure intramammary infections (IMI) in dairy cows during the dry period (DP). Nevertheless, the IMI cure is influenced by many factors and not all quarters benefit from antimicrobial dry cow treatment (DCT). To evaluate the true effect of antibiotic DCT compared to self-cure and the role of causative pathogens on the IMI cure, a retrospective cross-sectional study was performed. The analysis included 2987 quarters infected at dry-off (DO). Information on DCT, causative pathogens, somatic cell count, milk yield, amount of lactation, Body Condition Score, and season and year of DO were combined into categorical variables. A generalized linear mixed model with a random cow, farm and year effect and the binary outcome of bacteriological cure of IMI during the DP was conducted. In the final model, a significant effect (<i>p</i> < 0.05) on DP cure was seen for the DO season and the category of causative pathogens (categories being: <i>Staphylococcus aureus</i>, non-aureus staphylococci, streptococci, coliforms, ‘other Gram-negative bacteria’, ‘other Gram positive bacteria’, non-bacterial infections and mixed infections), while antibiotic DCT (vs. non-antibiotic DCT) only showed a significant effect in combination with the pathogen categories streptococci and ‘other Gram-positive bacteria’. |
| first_indexed | 2024-03-11T07:01:07Z |
| format | Article |
| id | doaj.art-02438b4cd1b94d00a650b6cfe86f927d |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-11T07:01:07Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-02438b4cd1b94d00a650b6cfe86f927d2023-11-17T09:12:50ZengMDPI AGAntibiotics2079-63822023-02-0112342910.3390/antibiotics12030429Effect of Antibiotic Compared to Non-Antibiotic Dry Cow Treatment on the Bacteriological Cure of Intramammary Infections during the Dry Period—A Retrospective Cross-Sectional StudyStephanie Müller0Julia Nitz1Anne Tellen2Doris Klocke3Volker Krömker4Faculty II, Microbiology, Hannover University of Applied Sciences and Arts, Heisterbergallee 10a, 30453 Hannover, GermanyFaculty II, Microbiology, Hannover University of Applied Sciences and Arts, Heisterbergallee 10a, 30453 Hannover, GermanyFaculty II, Microbiology, Hannover University of Applied Sciences and Arts, Heisterbergallee 10a, 30453 Hannover, GermanyFaculty II, Microbiology, Hannover University of Applied Sciences and Arts, Heisterbergallee 10a, 30453 Hannover, GermanyFaculty of Health and Medical Sciences, Department of Veterinary and Animal Sciences, Section for Production, Nutrition and Health, University of Copenhagen, Grønnegårdsvej 2, 1870 Frederiksberg, DenmarkAntimicrobials are widely used to cure intramammary infections (IMI) in dairy cows during the dry period (DP). Nevertheless, the IMI cure is influenced by many factors and not all quarters benefit from antimicrobial dry cow treatment (DCT). To evaluate the true effect of antibiotic DCT compared to self-cure and the role of causative pathogens on the IMI cure, a retrospective cross-sectional study was performed. The analysis included 2987 quarters infected at dry-off (DO). Information on DCT, causative pathogens, somatic cell count, milk yield, amount of lactation, Body Condition Score, and season and year of DO were combined into categorical variables. A generalized linear mixed model with a random cow, farm and year effect and the binary outcome of bacteriological cure of IMI during the DP was conducted. In the final model, a significant effect (<i>p</i> < 0.05) on DP cure was seen for the DO season and the category of causative pathogens (categories being: <i>Staphylococcus aureus</i>, non-aureus staphylococci, streptococci, coliforms, ‘other Gram-negative bacteria’, ‘other Gram positive bacteria’, non-bacterial infections and mixed infections), while antibiotic DCT (vs. non-antibiotic DCT) only showed a significant effect in combination with the pathogen categories streptococci and ‘other Gram-positive bacteria’.https://www.mdpi.com/2079-6382/12/3/429dairy cowsantimicrobialsselective dry cow treatmentteat sealantudder healthsubclinical mastitis |
| spellingShingle | Stephanie Müller Julia Nitz Anne Tellen Doris Klocke Volker Krömker Effect of Antibiotic Compared to Non-Antibiotic Dry Cow Treatment on the Bacteriological Cure of Intramammary Infections during the Dry Period—A Retrospective Cross-Sectional Study Antibiotics dairy cows antimicrobials selective dry cow treatment teat sealant udder health subclinical mastitis |
| title | Effect of Antibiotic Compared to Non-Antibiotic Dry Cow Treatment on the Bacteriological Cure of Intramammary Infections during the Dry Period—A Retrospective Cross-Sectional Study |
| title_full | Effect of Antibiotic Compared to Non-Antibiotic Dry Cow Treatment on the Bacteriological Cure of Intramammary Infections during the Dry Period—A Retrospective Cross-Sectional Study |
| title_fullStr | Effect of Antibiotic Compared to Non-Antibiotic Dry Cow Treatment on the Bacteriological Cure of Intramammary Infections during the Dry Period—A Retrospective Cross-Sectional Study |
| title_full_unstemmed | Effect of Antibiotic Compared to Non-Antibiotic Dry Cow Treatment on the Bacteriological Cure of Intramammary Infections during the Dry Period—A Retrospective Cross-Sectional Study |
| title_short | Effect of Antibiotic Compared to Non-Antibiotic Dry Cow Treatment on the Bacteriological Cure of Intramammary Infections during the Dry Period—A Retrospective Cross-Sectional Study |
| title_sort | effect of antibiotic compared to non antibiotic dry cow treatment on the bacteriological cure of intramammary infections during the dry period a retrospective cross sectional study |
| topic | dairy cows antimicrobials selective dry cow treatment teat sealant udder health subclinical mastitis |
| url | https://www.mdpi.com/2079-6382/12/3/429 |
| work_keys_str_mv | AT stephaniemuller effectofantibioticcomparedtononantibioticdrycowtreatmentonthebacteriologicalcureofintramammaryinfectionsduringthedryperiodaretrospectivecrosssectionalstudy AT julianitz effectofantibioticcomparedtononantibioticdrycowtreatmentonthebacteriologicalcureofintramammaryinfectionsduringthedryperiodaretrospectivecrosssectionalstudy AT annetellen effectofantibioticcomparedtononantibioticdrycowtreatmentonthebacteriologicalcureofintramammaryinfectionsduringthedryperiodaretrospectivecrosssectionalstudy AT dorisklocke effectofantibioticcomparedtononantibioticdrycowtreatmentonthebacteriologicalcureofintramammaryinfectionsduringthedryperiodaretrospectivecrosssectionalstudy AT volkerkromker effectofantibioticcomparedtononantibioticdrycowtreatmentonthebacteriologicalcureofintramammaryinfectionsduringthedryperiodaretrospectivecrosssectionalstudy |