The leprosy reaction is associated with salivary anti-Porphyromonas gingivalis IgA antibodies
Abstract The aim of the study was to evaluate the association between salivary anti-Porphyromonas gingivalis IgA antibodies and the leprosy reaction. The levels of salivary anti - P. gingivalis IgA antibodies, together with salivary flow and pH were measured in individuals diagnosed with leprosy and...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-07-01
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| Series: | AMB Express |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13568-023-01576-1 |
| _version_ | 1797784397237190656 |
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| author | Michelle Miranda Lopes Falcão Johelle Santana Passos-Soares Paulo Roberto Lima Machado Isaac Suzart Gomes-Filho Lucas Pedreira de Carvalho Elisangela Jesus de Campos Mariana Costa Calheira Patrícia Mares de Miranda Rebeca Pereira Bulhosa Santos José Tadeu Raynal Rocha Filho Antonio Pedro Froes de Farias Taiana Peixoto Roberto Meyer Nascimento Gregory John Seymour Soraya Castro Trindade |
| author_facet | Michelle Miranda Lopes Falcão Johelle Santana Passos-Soares Paulo Roberto Lima Machado Isaac Suzart Gomes-Filho Lucas Pedreira de Carvalho Elisangela Jesus de Campos Mariana Costa Calheira Patrícia Mares de Miranda Rebeca Pereira Bulhosa Santos José Tadeu Raynal Rocha Filho Antonio Pedro Froes de Farias Taiana Peixoto Roberto Meyer Nascimento Gregory John Seymour Soraya Castro Trindade |
| author_sort | Michelle Miranda Lopes Falcão |
| collection | DOAJ |
| description | Abstract The aim of the study was to evaluate the association between salivary anti-Porphyromonas gingivalis IgA antibodies and the leprosy reaction. The levels of salivary anti - P. gingivalis IgA antibodies, together with salivary flow and pH were measured in individuals diagnosed with leprosy and associated with the development of the leprosy reaction. Saliva was collected from 202 individuals diagnosed with leprosy at a reference leprosy treatment center, 106 cases with the leprosy reaction and 96 controls without the leprosy reaction. Anti - P. gingivalis IgA was evaluated by indirect immunoenzyme assay. Non-conditional logistic regression analysis was employed to estimate the association between antibody levels and the leprosy reaction. There was a positive statistically significant association between the levels of anti - P. gingivalis IgA and the presence of the leprosy reaction, controlling for confounders: age, sex, level of education and alcoholic beverage consumption: ORajusted: 2.55; IC 95%: 1.34–4.87. Individuals with leprosy who had high levels of salivary anti - P. gingivalis IgA had approximately twice as many chances of developing the leprosy reaction. The findings suggest a possible relationship between salivary anti - P. gingivalis IgA antibodies and the leprosy reaction. |
| first_indexed | 2024-03-13T00:39:18Z |
| format | Article |
| id | doaj.art-0243a3ddd3df4697aa061931b77684ca |
| institution | Directory Open Access Journal |
| issn | 2191-0855 |
| language | English |
| last_indexed | 2024-03-13T00:39:18Z |
| publishDate | 2023-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | AMB Express |
| spelling | doaj.art-0243a3ddd3df4697aa061931b77684ca2023-07-09T11:25:57ZengSpringerOpenAMB Express2191-08552023-07-011311810.1186/s13568-023-01576-1The leprosy reaction is associated with salivary anti-Porphyromonas gingivalis IgA antibodiesMichelle Miranda Lopes Falcão0Johelle Santana Passos-Soares1Paulo Roberto Lima Machado2Isaac Suzart Gomes-Filho3Lucas Pedreira de Carvalho4Elisangela Jesus de Campos5Mariana Costa Calheira6Patrícia Mares de Miranda7Rebeca Pereira Bulhosa Santos8José Tadeu Raynal Rocha Filho9Antonio Pedro Froes de Farias10Taiana Peixoto11Roberto Meyer Nascimento12Gregory John Seymour13Soraya Castro Trindade14Department of Health, State University of Feira de SantanaDepartment of Health, State University of Feira de SantanaImmunology Service, University Hospital Prof. Edgar Santos Federal University of BahiaDepartment of Health, State University of Feira de SantanaImmunology and Molecular Biology Laboratory, Federal University of BahiaOral Biochemistry Laboratory, Health Sciences Institute, Federal University of BahiaPostgraduate Program in Immunology, Federal University of BahiaPostgraduate Program in Immunology, Federal University of BahiaPostgraduate Program in Immunology, Federal University of BahiaImmunology and Molecular Biology Laboratory, Federal University of BahiaPostgraduate Program in Immunology, Federal University of BahiaSchool of Dentistry, Federal University of BahiaImmunology and Molecular Biology Laboratory, Federal University of BahiaSchool of Dentistry, The University of QueenslandDepartment of Health, State University of Feira de SantanaAbstract The aim of the study was to evaluate the association between salivary anti-Porphyromonas gingivalis IgA antibodies and the leprosy reaction. The levels of salivary anti - P. gingivalis IgA antibodies, together with salivary flow and pH were measured in individuals diagnosed with leprosy and associated with the development of the leprosy reaction. Saliva was collected from 202 individuals diagnosed with leprosy at a reference leprosy treatment center, 106 cases with the leprosy reaction and 96 controls without the leprosy reaction. Anti - P. gingivalis IgA was evaluated by indirect immunoenzyme assay. Non-conditional logistic regression analysis was employed to estimate the association between antibody levels and the leprosy reaction. There was a positive statistically significant association between the levels of anti - P. gingivalis IgA and the presence of the leprosy reaction, controlling for confounders: age, sex, level of education and alcoholic beverage consumption: ORajusted: 2.55; IC 95%: 1.34–4.87. Individuals with leprosy who had high levels of salivary anti - P. gingivalis IgA had approximately twice as many chances of developing the leprosy reaction. The findings suggest a possible relationship between salivary anti - P. gingivalis IgA antibodies and the leprosy reaction.https://doi.org/10.1186/s13568-023-01576-1SalivaPeriodontitisHumoral responseLeprosy |
| spellingShingle | Michelle Miranda Lopes Falcão Johelle Santana Passos-Soares Paulo Roberto Lima Machado Isaac Suzart Gomes-Filho Lucas Pedreira de Carvalho Elisangela Jesus de Campos Mariana Costa Calheira Patrícia Mares de Miranda Rebeca Pereira Bulhosa Santos José Tadeu Raynal Rocha Filho Antonio Pedro Froes de Farias Taiana Peixoto Roberto Meyer Nascimento Gregory John Seymour Soraya Castro Trindade The leprosy reaction is associated with salivary anti-Porphyromonas gingivalis IgA antibodies AMB Express Saliva Periodontitis Humoral response Leprosy |
| title | The leprosy reaction is associated with salivary anti-Porphyromonas gingivalis IgA antibodies |
| title_full | The leprosy reaction is associated with salivary anti-Porphyromonas gingivalis IgA antibodies |
| title_fullStr | The leprosy reaction is associated with salivary anti-Porphyromonas gingivalis IgA antibodies |
| title_full_unstemmed | The leprosy reaction is associated with salivary anti-Porphyromonas gingivalis IgA antibodies |
| title_short | The leprosy reaction is associated with salivary anti-Porphyromonas gingivalis IgA antibodies |
| title_sort | leprosy reaction is associated with salivary anti porphyromonas gingivalis iga antibodies |
| topic | Saliva Periodontitis Humoral response Leprosy |
| url | https://doi.org/10.1186/s13568-023-01576-1 |
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