Rostral Anterior Cingulate Cortex–Ventrolateral Periaqueductal Gray Circuit Underlies Electroacupuncture to Alleviate Hyperalgesia but Not Anxiety-Like Behaviors in Mice With Spared Nerve Injury

Rostral Anterior Cingulate Cortex–Ventrolateral Periaqueductal Gray Circuit Underlies Electroacupuncture to Alleviate Hyperalgesia but Not Anxiety-Like Behaviors in Mice With Spared Nerve Injury

Neuropathic pain is a common cause of chronic pain and is often accompanied by negative emotions, making it complex and difficult to treat. However, the neural circuit mechanisms underlying these symptoms remain unclear. Herein, we present a novel pathway associated with comorbid chronic pain and an...

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Bibliographic Details
Main Authors: Xixiao Zhu, Yingling Xu, Zui Shen, Haiyan Zhang, Siqi Xiao, Yichen Zhu, Mengwei Wu, Yeqing Chen, Zemin Wu, Yunyun Xu, Xiaofen He, Boyu Liu, Jinggen Liu, Junying Du, Jing Sun, Jianqiao Fang, Xiaomei Shao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Neuroscience
Subjects:
chronic pain
neuropathic pain
anxiety
rostral anterior cingulated cortex
periaqueductal gray
electroacupuncture
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.757628/full

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