Exosomal long non-coding RNAs: novel molecules in gastrointestinal cancers’ progression and diagnosis
Gastrointestinal (GI) cancers arise in the GI tract and accessory organs, including the mouth, esophagus, stomach, liver, biliary tract, pancreas, small intestine, large intestine, and rectum. GI cancers are a major cause of cancer-related morbidity and mortality worldwide. Exosomes act as mediators...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1014949/full |
| _version_ | 1811200698496319488 |
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| author | Mohammad Roshani Ghazaleh Baniebrahimi Mahboubeh Mousavi Noushid Zare Reza Sadeghi Reza Salarinia Amirhossein Sheida Amirhossein Sheida Danial Molavizadeh Danial Molavizadeh Sara Sadeghi Sara Sadeghi Farzaneh Moammer Mohammad Reza Zolfaghari Hamed Mirzaei |
| author_facet | Mohammad Roshani Ghazaleh Baniebrahimi Mahboubeh Mousavi Noushid Zare Reza Sadeghi Reza Salarinia Amirhossein Sheida Amirhossein Sheida Danial Molavizadeh Danial Molavizadeh Sara Sadeghi Sara Sadeghi Farzaneh Moammer Mohammad Reza Zolfaghari Hamed Mirzaei |
| author_sort | Mohammad Roshani |
| collection | DOAJ |
| description | Gastrointestinal (GI) cancers arise in the GI tract and accessory organs, including the mouth, esophagus, stomach, liver, biliary tract, pancreas, small intestine, large intestine, and rectum. GI cancers are a major cause of cancer-related morbidity and mortality worldwide. Exosomes act as mediators of cell-to-cell communication, with pleiotropic activity in the regulation of homeostasis, and can be markers for diseases. Non-coding RNAs (ncRNAs), such as long non-coding RNAs (lncRNAs), can be transported by exosomes derived from tumor cells or non-tumor cells. They can be taken by recipient cells to alter their function or remodel the tumor microenvironment. Moreover, due to their uniquely low immunogenicity and excellent stability, exosomes can be used as natural carriers for therapeutic ncRNAs in vivo. Exosomal lncRNAs have a crucial role in regulating several cancer processes, including angiogenesis, proliferation, drug resistance, metastasis, and immunomodulation. Exosomal lncRNA levels frequently alter according to the onset and progression of cancer. Exosomal lncRNAs can therefore be employed as biomarkers for the diagnosis and prognosis of cancer. Exosomal lncRNAs can also monitor the patient’s response to chemotherapy while also serving as potential targets for cancer treatment. Here, we discuss the role of exosomal lncRNAs in the biology and possible future treatment of GI cancer. |
| first_indexed | 2024-04-12T02:08:35Z |
| format | Article |
| id | doaj.art-0246cae8dbb440b58fa46494f4552d61 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T02:08:35Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-0246cae8dbb440b58fa46494f4552d612022-12-22T03:52:28ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-12-011210.3389/fonc.2022.10149491014949Exosomal long non-coding RNAs: novel molecules in gastrointestinal cancers’ progression and diagnosisMohammad Roshani0Ghazaleh Baniebrahimi1Mahboubeh Mousavi2Noushid Zare3Reza Sadeghi4Reza Salarinia5Amirhossein Sheida6Amirhossein Sheida7Danial Molavizadeh8Danial Molavizadeh9Sara Sadeghi10Sara Sadeghi11Farzaneh Moammer12Mohammad Reza Zolfaghari13Hamed Mirzaei14Internal Medicine and Gastroenterology, Colorectal Research Center, Iran University of Medical Sciences, Tehran, IranDepartment of Pediatric Dentistry, School of Dentistry, Tehran University of Medical Sciences, Tehran, IranDepartment of Anatomy, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, IranFaculty of Pharmacy, Tehran University of Medical Science, Tehran, IranSchool of Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Advanced Technologies, School of Medicine, North Khorasan University of Sciences, Bojnurd, IranSchool of Medicine, Kashan University of Medical Sciences, Kashan, IranResearch Committee, Kashan University of Medical Sciences, Kashan, IranSchool of Medicine, Kashan University of Medical Sciences, Kashan, IranResearch Committee, Kashan University of Medical Sciences, Kashan, IranSchool of Medicine, Kashan University of Medical Sciences, Kashan, IranResearch Committee, Kashan University of Medical Sciences, Kashan, IranResearch Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran0Department of Microbiology, Qom Branch, Islamic Azad University, Qom, Iran1Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, IranGastrointestinal (GI) cancers arise in the GI tract and accessory organs, including the mouth, esophagus, stomach, liver, biliary tract, pancreas, small intestine, large intestine, and rectum. GI cancers are a major cause of cancer-related morbidity and mortality worldwide. Exosomes act as mediators of cell-to-cell communication, with pleiotropic activity in the regulation of homeostasis, and can be markers for diseases. Non-coding RNAs (ncRNAs), such as long non-coding RNAs (lncRNAs), can be transported by exosomes derived from tumor cells or non-tumor cells. They can be taken by recipient cells to alter their function or remodel the tumor microenvironment. Moreover, due to their uniquely low immunogenicity and excellent stability, exosomes can be used as natural carriers for therapeutic ncRNAs in vivo. Exosomal lncRNAs have a crucial role in regulating several cancer processes, including angiogenesis, proliferation, drug resistance, metastasis, and immunomodulation. Exosomal lncRNA levels frequently alter according to the onset and progression of cancer. Exosomal lncRNAs can therefore be employed as biomarkers for the diagnosis and prognosis of cancer. Exosomal lncRNAs can also monitor the patient’s response to chemotherapy while also serving as potential targets for cancer treatment. Here, we discuss the role of exosomal lncRNAs in the biology and possible future treatment of GI cancer.https://www.frontiersin.org/articles/10.3389/fonc.2022.1014949/fullgastrointestinal cancernon-coding RNAsexosomelong non-coding RNAspathogenesis |
| spellingShingle | Mohammad Roshani Ghazaleh Baniebrahimi Mahboubeh Mousavi Noushid Zare Reza Sadeghi Reza Salarinia Amirhossein Sheida Amirhossein Sheida Danial Molavizadeh Danial Molavizadeh Sara Sadeghi Sara Sadeghi Farzaneh Moammer Mohammad Reza Zolfaghari Hamed Mirzaei Exosomal long non-coding RNAs: novel molecules in gastrointestinal cancers’ progression and diagnosis Frontiers in Oncology gastrointestinal cancer non-coding RNAs exosome long non-coding RNAs pathogenesis |
| title | Exosomal long non-coding RNAs: novel molecules in gastrointestinal cancers’ progression and diagnosis |
| title_full | Exosomal long non-coding RNAs: novel molecules in gastrointestinal cancers’ progression and diagnosis |
| title_fullStr | Exosomal long non-coding RNAs: novel molecules in gastrointestinal cancers’ progression and diagnosis |
| title_full_unstemmed | Exosomal long non-coding RNAs: novel molecules in gastrointestinal cancers’ progression and diagnosis |
| title_short | Exosomal long non-coding RNAs: novel molecules in gastrointestinal cancers’ progression and diagnosis |
| title_sort | exosomal long non coding rnas novel molecules in gastrointestinal cancers progression and diagnosis |
| topic | gastrointestinal cancer non-coding RNAs exosome long non-coding RNAs pathogenesis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1014949/full |
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