Serratia marcescens as a cause of unfavorable outcome in the twin pregnancy
Several Serratia species are widely distributed in nature, but Serratia marcescens is the only species frequently isolated in hospitals. This pathogen is mainly responsible for nosocomial infection, mostly in immunocompromised hosts. A 26-year-old woman with a twin pregnancy, regularly controlled, w...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2020-12-01
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| Series: | Open Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/med-2021-0205 |
| _version_ | 1811202918385188864 |
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| author | Kljakić Duško Milosavljević Miloš Z. Jovanović Milan Popović Vesna Čolaković Raičević Saša |
| author_facet | Kljakić Duško Milosavljević Miloš Z. Jovanović Milan Popović Vesna Čolaković Raičević Saša |
| author_sort | Kljakić Duško |
| collection | DOAJ |
| description | Several Serratia species are widely distributed in nature, but Serratia marcescens is the only species frequently isolated in hospitals. This pathogen is mainly responsible for nosocomial infection, mostly in immunocompromised hosts. A 26-year-old woman with a twin pregnancy, regularly controlled, was hospitalized at 24 + 5 weeks of gestation due to scant vaginal bleeding, lower abdominal pain, and body temperature up to 37.5°C. Gynecological examination revealed bleeding accompanied by dilatation of the cervix. The laboratory analyses revealed leukocytosis with elevated C-reactive protein (CRP). Treatment was initiated with intravenous antibiotic administration. After admission, fetal membranes spontaneously ruptured, and an extremely preterm dichorionic female twin birth occurred at 25 + 0 weeks of gestation. Both infants died two days after labor. Pathological and microbiological analyses revealed chorioamnionitis caused by S. marcescens. According to the antibiogram, antibiotic treatment was continued for the next 7 days. The examination of cervical and vaginal discharge samples was negative three days and two weeks after therapy. S. marcescens may cause spontaneous miscarriages and, in this important case, caused loss of discordant twins in an extremely preterm birth by an immunocompetent patient. Infection by S. marcescens cannot be excluded as a cause of discordant growth and needs to be confirmed by further research. |
| first_indexed | 2024-04-12T02:47:03Z |
| format | Article |
| id | doaj.art-024afcc2870747eda4d7a5ecf0a2a4b1 |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-04-12T02:47:03Z |
| publishDate | 2020-12-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj.art-024afcc2870747eda4d7a5ecf0a2a4b12022-12-22T03:51:08ZengDe GruyterOpen Medicine2391-54632020-12-01161818610.1515/med-2021-0205med-2021-0205Serratia marcescens as a cause of unfavorable outcome in the twin pregnancyKljakić Duško0Milosavljević Miloš Z.1Jovanović Milan2Popović Vesna Čolaković3Raičević Saša4Department of Gynecology, General Hospital Bar, Bar, MontenegroDepartment of Pathology, University Medical Center Kragujevac, Kragujevac, SerbiaClinic for Infectious Diseases, Clinical Center of Montenegro, Podgorica, MontenegroClinic of Gynecology and Obstetrics, Clinical Center of Montenegro, Podgorica, MontenegroClinic of Gynecology and Obstetrics, Clinical Center of Montenegro, Podgorica, MontenegroSeveral Serratia species are widely distributed in nature, but Serratia marcescens is the only species frequently isolated in hospitals. This pathogen is mainly responsible for nosocomial infection, mostly in immunocompromised hosts. A 26-year-old woman with a twin pregnancy, regularly controlled, was hospitalized at 24 + 5 weeks of gestation due to scant vaginal bleeding, lower abdominal pain, and body temperature up to 37.5°C. Gynecological examination revealed bleeding accompanied by dilatation of the cervix. The laboratory analyses revealed leukocytosis with elevated C-reactive protein (CRP). Treatment was initiated with intravenous antibiotic administration. After admission, fetal membranes spontaneously ruptured, and an extremely preterm dichorionic female twin birth occurred at 25 + 0 weeks of gestation. Both infants died two days after labor. Pathological and microbiological analyses revealed chorioamnionitis caused by S. marcescens. According to the antibiogram, antibiotic treatment was continued for the next 7 days. The examination of cervical and vaginal discharge samples was negative three days and two weeks after therapy. S. marcescens may cause spontaneous miscarriages and, in this important case, caused loss of discordant twins in an extremely preterm birth by an immunocompetent patient. Infection by S. marcescens cannot be excluded as a cause of discordant growth and needs to be confirmed by further research.https://doi.org/10.1515/med-2021-0205twins dizygoticfetal growth retardationpremature birthinfectious pregnancy complicationsserratia marcescens |
| spellingShingle | Kljakić Duško Milosavljević Miloš Z. Jovanović Milan Popović Vesna Čolaković Raičević Saša Serratia marcescens as a cause of unfavorable outcome in the twin pregnancy Open Medicine twins dizygotic fetal growth retardation premature birth infectious pregnancy complications serratia marcescens |
| title | Serratia marcescens as a cause of unfavorable outcome in the twin pregnancy |
| title_full | Serratia marcescens as a cause of unfavorable outcome in the twin pregnancy |
| title_fullStr | Serratia marcescens as a cause of unfavorable outcome in the twin pregnancy |
| title_full_unstemmed | Serratia marcescens as a cause of unfavorable outcome in the twin pregnancy |
| title_short | Serratia marcescens as a cause of unfavorable outcome in the twin pregnancy |
| title_sort | serratia marcescens as a cause of unfavorable outcome in the twin pregnancy |
| topic | twins dizygotic fetal growth retardation premature birth infectious pregnancy complications serratia marcescens |
| url | https://doi.org/10.1515/med-2021-0205 |
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