Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter
The molecular mechanism by which acetylation regulates manganese superoxide dismutase (MnSOD) activity and its oncogenicity is unclear. Here the authors show that an acetylation mimicking MnSOD mutant is a monomer, has peroxidase function and acts as a tumor promoting factor.
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-10352-4 |
| _version_ | 1818992663980933120 |
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| author | Yueming Zhu Xianghui Zou Angela E. Dean Joseph O’ Brien Yucheng Gao Elizabeth L. Tran Seong-Hoon Park Guoxiang Liu Matthew B. Kieffer Haiyan Jiang Melissa E. Stauffer Robert Hart Songhua Quan Karla J. F. Satchell Nobuo Horikoshi Marcelo Bonini David Gius |
| author_facet | Yueming Zhu Xianghui Zou Angela E. Dean Joseph O’ Brien Yucheng Gao Elizabeth L. Tran Seong-Hoon Park Guoxiang Liu Matthew B. Kieffer Haiyan Jiang Melissa E. Stauffer Robert Hart Songhua Quan Karla J. F. Satchell Nobuo Horikoshi Marcelo Bonini David Gius |
| author_sort | Yueming Zhu |
| collection | DOAJ |
| description | The molecular mechanism by which acetylation regulates manganese superoxide dismutase (MnSOD) activity and its oncogenicity is unclear. Here the authors show that an acetylation mimicking MnSOD mutant is a monomer, has peroxidase function and acts as a tumor promoting factor. |
| first_indexed | 2024-12-20T20:29:45Z |
| format | Article |
| id | doaj.art-024c2a17f581441ca1d27fe75c08a597 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T20:29:45Z |
| publishDate | 2019-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-024c2a17f581441ca1d27fe75c08a5972022-12-21T19:27:23ZengNature PortfolioNature Communications2041-17232019-06-0110111510.1038/s41467-019-10352-4Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoterYueming Zhu0Xianghui Zou1Angela E. Dean2Joseph O’ Brien3Yucheng Gao4Elizabeth L. Tran5Seong-Hoon Park6Guoxiang Liu7Matthew B. Kieffer8Haiyan Jiang9Melissa E. Stauffer10Robert Hart11Songhua Quan12Karla J. F. Satchell13Nobuo Horikoshi14Marcelo Bonini15David Gius16Department of Radiation Oncology, Feinberg School of Medicine, Northwestern UniversityDepartment of Radiation Oncology, Feinberg School of Medicine, Northwestern UniversityDepartment of Radiation Oncology, Feinberg School of Medicine, Northwestern UniversityDepartment of Radiation Oncology, Feinberg School of Medicine, Northwestern UniversityDepartment of Radiation Oncology, Feinberg School of Medicine, Northwestern UniversityDepartment of Radiation Oncology, Feinberg School of Medicine, Northwestern UniversityDepartment of Radiation Oncology, Feinberg School of Medicine, Northwestern UniversityDepartment of Radiation Oncology, Feinberg School of Medicine, Northwestern UniversityDepartment of Microbiology-Immunology, Feinberg School of Medicine, Northwestern UniversityDepartment of Radiation Oncology, Feinberg School of Medicine, Northwestern UniversityScientific Editing SolutionsDepartment of Medicine, University of Illinois at ChicagoDepartment of Radiation Oncology, Feinberg School of Medicine, Northwestern UniversityDepartment of Microbiology-Immunology, Feinberg School of Medicine, Northwestern UniversityDepartment of Radiation Oncology, Feinberg School of Medicine, Northwestern UniversityDepartment of Medicine, University of Illinois at ChicagoDepartment of Radiation Oncology, Feinberg School of Medicine, Northwestern UniversityThe molecular mechanism by which acetylation regulates manganese superoxide dismutase (MnSOD) activity and its oncogenicity is unclear. Here the authors show that an acetylation mimicking MnSOD mutant is a monomer, has peroxidase function and acts as a tumor promoting factor.https://doi.org/10.1038/s41467-019-10352-4 |
| spellingShingle | Yueming Zhu Xianghui Zou Angela E. Dean Joseph O’ Brien Yucheng Gao Elizabeth L. Tran Seong-Hoon Park Guoxiang Liu Matthew B. Kieffer Haiyan Jiang Melissa E. Stauffer Robert Hart Songhua Quan Karla J. F. Satchell Nobuo Horikoshi Marcelo Bonini David Gius Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter Nature Communications |
| title | Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter |
| title_full | Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter |
| title_fullStr | Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter |
| title_full_unstemmed | Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter |
| title_short | Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter |
| title_sort | lysine 68 acetylation directs mnsod as a tetrameric detoxification complex versus a monomeric tumor promoter |
| url | https://doi.org/10.1038/s41467-019-10352-4 |
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