LINC00922 decoys SIRT3 to facilitate the metastasis of colorectal cancer through up-regulation the H3K27 crotonylation of ETS1 promoter

LINC00922 decoys SIRT3 to facilitate the metastasis of colorectal cancer through up-regulation the H3K27 crotonylation of ETS1 promoter

Abstract Background Lysine crotonylation (Kcr) is up-regulation in colorectal cancer (CRC) tissues, while its specific contribution remains uncertain. This study aimed to elucidate the role and mechanism of crotonylation on Lys27 of histone H3 (H3K27cr) in facilitating CRC metastasis. Methods Immuno...

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Bibliographic Details
Main Authors: Meijian Liao, Xiaolin Sun, Wendan Zheng, Mengdi Wu, Yifan Wang, Jia Yao, Yu Ma, Shoucui Gao, Dongsheng Pei
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Molecular Cancer
Subjects:
Colorectal cancer
Metastasis
LINC00922
H3K27cr
SIRT3
Online Access:https://doi.org/10.1186/s12943-023-01859-y

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