PPARγ attenuates cellular senescence of alveolar macrophages in asthma-COPD overlap

PPARγ attenuates cellular senescence of alveolar macrophages in asthma-COPD overlap

Abstract Background Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) represents a complex condition characterized by shared clinical and pathophysiological features of asthma and COPD in older individuals. However, the pathophysiology of ACO remains unexplored. We aimed to identify...

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Bibliographic Details
Main Authors: Rongjun Wan, Prakhyath Srikaram, Shaobing Xie, Qiong Chen, Chengping Hu, Mei Wan, Yuanyuan Li, Peisong Gao
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Respiratory Research
Subjects:
ACO
Asthma
COPD
Macrophages
Senescence
PPARγ
Online Access:https://doi.org/10.1186/s12931-024-02790-6

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