Lytic viral replication and immunopathology in a cytomegalovirus-induced mouse model of secondary hemophagocytic lymphohistiocytosis

Lytic viral replication and immunopathology in a cytomegalovirus-induced mouse model of secondary hemophagocytic lymphohistiocytosis

Abstract Background Hemophagocytic lymphohistiocytosis (HLH) is a rare immunological disorder caused by unbridled activation of T cells and macrophages, culminating in a life-threatening cytokine storm. A genetic and acquired subtype are distinguished, termed primary and secondary HLH, respectively....

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Bibliographic Details
Main Authors: Ellen Brisse, Maya Imbrechts, Tania Mitera, Jessica Vandenhaute, Carine H. Wouters, Robert Snoeck, Graciela Andrei, Patrick Matthys
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Virology Journal
Subjects:
Hemophagocytic lymphohistiocytosis
HLH
macrophage activation syndrome
MAS
mouse model
mouse cytomegalovirus
Online Access:http://link.springer.com/article/10.1186/s12985-017-0908-0

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