Parameters to Predict the Outcome of Severe and Critical COVID-19 Patients when Admitted to the Hospital
Manifestations of COVID-19 are diverse and range from asymptomatic to severe, critical illness and death. Cases requiring hospital care (in severe and critical illnesses) are associated with comorbidities and hyperactivation of the immune system. Therefore, in this exploratory observational study, w...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/4/1323 |
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| author | Sonia del Carmen Chávez-Ocaña Juan Carlos Bravata-Alcántara Iliana Alejandra Cortés-Ortiz Arturo Reyes-Sandoval Jazmín García-Machorro Norma Estela Herrera-Gonzalez |
| author_facet | Sonia del Carmen Chávez-Ocaña Juan Carlos Bravata-Alcántara Iliana Alejandra Cortés-Ortiz Arturo Reyes-Sandoval Jazmín García-Machorro Norma Estela Herrera-Gonzalez |
| author_sort | Sonia del Carmen Chávez-Ocaña |
| collection | DOAJ |
| description | Manifestations of COVID-19 are diverse and range from asymptomatic to severe, critical illness and death. Cases requiring hospital care (in severe and critical illnesses) are associated with comorbidities and hyperactivation of the immune system. Therefore, in this exploratory observational study, we analyzed which parameters are associated with mortality. We evaluated: demographic characteristics (age, sex and comorbidities), laboratory data (albumin, leukocytes, lymphocytes, platelets, ferritin), days of hospital stay, interleukins (IL-2, IL-6, IL-7, IL-10, IL-17) and sP-selectin in 40 Mexican patients admitted to medical emergencies with a confirmed diagnosis of COVID-19, a complete clinical record, and who signed the informed consent. Twenty severe (they required intermediate care with non-invasive ventilation) and twenty critically ill patients (they required mechanical ventilation) were classified, and these were subsequently compared with healthy and recovered subjects. A significant difference was found between the hospitalized groups in the parameters of age, ferritin, days of hospital stay and death with <i>p</i> values = 0.0145, <i>p</i> = 0.0441, <i>p</i> = 0.0001 and <i>p</i> = 0.0001, respectively. In the determination of cytokines and P-selectin, a significant difference was found between the following groups: recovered patients and healthy volunteers compared with hospitalized patients in severe and critical condition. Importantly, IL-7 remained elevated one year later in recovered patients. Taken together, these values determined at the time of hospital admission could be useful to monitor patients closely and evaluate in-hospital progress, hospital discharge, and out-of-hospital progress. |
| first_indexed | 2024-03-11T08:38:17Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T08:38:17Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-0251b011a99a491ba76f6dc3a850f70f2023-11-16T21:17:56ZengMDPI AGJournal of Clinical Medicine2077-03832023-02-01124132310.3390/jcm12041323Parameters to Predict the Outcome of Severe and Critical COVID-19 Patients when Admitted to the HospitalSonia del Carmen Chávez-Ocaña0Juan Carlos Bravata-Alcántara1Iliana Alejandra Cortés-Ortiz2Arturo Reyes-Sandoval3Jazmín García-Machorro4Norma Estela Herrera-Gonzalez5Genetics and Molecular Diagnosis Laboratory, Juárez de Mexico Hospital, Mexico City 07760, MexicoGenetics and Molecular Diagnosis Laboratory, Juárez de Mexico Hospital, Mexico City 07760, MexicoBacteriology Laboratory, Juárez de Mexico Hospital, Mexico City 07760, MexicoThe Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UKLaboratorio de Medicina de Conservación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, MexicoMolecular Oncology Lab, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n, Col. Casco de Santo Tomás, Ciudad de México 11340, MexicoManifestations of COVID-19 are diverse and range from asymptomatic to severe, critical illness and death. Cases requiring hospital care (in severe and critical illnesses) are associated with comorbidities and hyperactivation of the immune system. Therefore, in this exploratory observational study, we analyzed which parameters are associated with mortality. We evaluated: demographic characteristics (age, sex and comorbidities), laboratory data (albumin, leukocytes, lymphocytes, platelets, ferritin), days of hospital stay, interleukins (IL-2, IL-6, IL-7, IL-10, IL-17) and sP-selectin in 40 Mexican patients admitted to medical emergencies with a confirmed diagnosis of COVID-19, a complete clinical record, and who signed the informed consent. Twenty severe (they required intermediate care with non-invasive ventilation) and twenty critically ill patients (they required mechanical ventilation) were classified, and these were subsequently compared with healthy and recovered subjects. A significant difference was found between the hospitalized groups in the parameters of age, ferritin, days of hospital stay and death with <i>p</i> values = 0.0145, <i>p</i> = 0.0441, <i>p</i> = 0.0001 and <i>p</i> = 0.0001, respectively. In the determination of cytokines and P-selectin, a significant difference was found between the following groups: recovered patients and healthy volunteers compared with hospitalized patients in severe and critical condition. Importantly, IL-7 remained elevated one year later in recovered patients. Taken together, these values determined at the time of hospital admission could be useful to monitor patients closely and evaluate in-hospital progress, hospital discharge, and out-of-hospital progress.https://www.mdpi.com/2077-0383/12/4/1323COVID-19severecriticalprogressingdeath |
| spellingShingle | Sonia del Carmen Chávez-Ocaña Juan Carlos Bravata-Alcántara Iliana Alejandra Cortés-Ortiz Arturo Reyes-Sandoval Jazmín García-Machorro Norma Estela Herrera-Gonzalez Parameters to Predict the Outcome of Severe and Critical COVID-19 Patients when Admitted to the Hospital Journal of Clinical Medicine COVID-19 severe critical progressing death |
| title | Parameters to Predict the Outcome of Severe and Critical COVID-19 Patients when Admitted to the Hospital |
| title_full | Parameters to Predict the Outcome of Severe and Critical COVID-19 Patients when Admitted to the Hospital |
| title_fullStr | Parameters to Predict the Outcome of Severe and Critical COVID-19 Patients when Admitted to the Hospital |
| title_full_unstemmed | Parameters to Predict the Outcome of Severe and Critical COVID-19 Patients when Admitted to the Hospital |
| title_short | Parameters to Predict the Outcome of Severe and Critical COVID-19 Patients when Admitted to the Hospital |
| title_sort | parameters to predict the outcome of severe and critical covid 19 patients when admitted to the hospital |
| topic | COVID-19 severe critical progressing death |
| url | https://www.mdpi.com/2077-0383/12/4/1323 |
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