Targeting the mechano-microenvironment and liver cancer stem cells: a promising therapeutic strategy for liver cancer
Over the past 2 decades, cancer stem cells (CSCs) have been identified as the root cause of cancer occurrence, progression, chemoradioresistance, recurrence, and metastasis. Targeting CSCs is a novel therapeutic strategy for cancer management and treatment. Liver cancer (LC) is a malignant disease t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
China Anti-Cancer Association
2023-11-01
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| Series: | Cancer Biology & Medicine |
| Subjects: | |
| Online Access: | https://www.cancerbiomed.org/content/20/11/816 |
| _version_ | 1797404088619499520 |
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| author | Xiaorong Fu Yi Zhang Qing Luo Yang Ju Guanbin Song |
| author_facet | Xiaorong Fu Yi Zhang Qing Luo Yang Ju Guanbin Song |
| author_sort | Xiaorong Fu |
| collection | DOAJ |
| description | Over the past 2 decades, cancer stem cells (CSCs) have been identified as the root cause of cancer occurrence, progression, chemoradioresistance, recurrence, and metastasis. Targeting CSCs is a novel therapeutic strategy for cancer management and treatment. Liver cancer (LC) is a malignant disease that can endanger human health. Studies are increasingly suggesting that changes in the liver mechanical microenvironment are a primary driver triggering the occurrence and development of liver cancer. In this review, we summarize current understanding of the roles of the liver mechano-microenvironment and liver cancer stem cells (LCSCs) in liver cancer progression. We also discuss the relationship between the mechanical heterogeneity of liver cancer tissues and LCSC recruitment and metastasis. Finally, we highlight potential mechanosensitive molecules in LCSCs and mechanotherapy in liver cancer. Understanding the roles and regulatory mechanisms of the mechano-microenvironment and LCSCs may provide fundamental insights into liver cancer progression and aid in further development of novel therapeutic strategies. |
| first_indexed | 2024-03-09T02:49:51Z |
| format | Article |
| id | doaj.art-02526b61ca344ddca212293661cb3927 |
| institution | Directory Open Access Journal |
| issn | 2095-3941 |
| language | English |
| last_indexed | 2024-03-09T02:49:51Z |
| publishDate | 2023-11-01 |
| publisher | China Anti-Cancer Association |
| record_format | Article |
| series | Cancer Biology & Medicine |
| spelling | doaj.art-02526b61ca344ddca212293661cb39272023-12-05T11:51:53ZengChina Anti-Cancer AssociationCancer Biology & Medicine2095-39412023-11-01201181682910.20892/j.issn.2095-3941.2023.0229Targeting the mechano-microenvironment and liver cancer stem cells: a promising therapeutic strategy for liver cancerXiaorong Fu0Yi Zhang1Qing Luo2Yang Ju3Guanbin Song4School of Biology and Engineering, Guizhou Medical University, Guiyang 550000, ChinaDepartment of Mechanical Science and Engineering, Nagoya University, Nagoya 4648603, JapanCollege of Bioengineering, Chongqing University, Chongqing 400030, ChinaDepartment of Mechanical Science and Engineering, Nagoya University, Nagoya 4648603, JapanCollege of Bioengineering, Chongqing University, Chongqing 400030, ChinaOver the past 2 decades, cancer stem cells (CSCs) have been identified as the root cause of cancer occurrence, progression, chemoradioresistance, recurrence, and metastasis. Targeting CSCs is a novel therapeutic strategy for cancer management and treatment. Liver cancer (LC) is a malignant disease that can endanger human health. Studies are increasingly suggesting that changes in the liver mechanical microenvironment are a primary driver triggering the occurrence and development of liver cancer. In this review, we summarize current understanding of the roles of the liver mechano-microenvironment and liver cancer stem cells (LCSCs) in liver cancer progression. We also discuss the relationship between the mechanical heterogeneity of liver cancer tissues and LCSC recruitment and metastasis. Finally, we highlight potential mechanosensitive molecules in LCSCs and mechanotherapy in liver cancer. Understanding the roles and regulatory mechanisms of the mechano-microenvironment and LCSCs may provide fundamental insights into liver cancer progression and aid in further development of novel therapeutic strategies.https://www.cancerbiomed.org/content/20/11/816liver cancermechano-microenvironmentcancer stem cellstumor heterogeneitymechanotherapy |
| spellingShingle | Xiaorong Fu Yi Zhang Qing Luo Yang Ju Guanbin Song Targeting the mechano-microenvironment and liver cancer stem cells: a promising therapeutic strategy for liver cancer Cancer Biology & Medicine liver cancer mechano-microenvironment cancer stem cells tumor heterogeneity mechanotherapy |
| title | Targeting the mechano-microenvironment and liver cancer stem cells: a promising therapeutic strategy for liver cancer |
| title_full | Targeting the mechano-microenvironment and liver cancer stem cells: a promising therapeutic strategy for liver cancer |
| title_fullStr | Targeting the mechano-microenvironment and liver cancer stem cells: a promising therapeutic strategy for liver cancer |
| title_full_unstemmed | Targeting the mechano-microenvironment and liver cancer stem cells: a promising therapeutic strategy for liver cancer |
| title_short | Targeting the mechano-microenvironment and liver cancer stem cells: a promising therapeutic strategy for liver cancer |
| title_sort | targeting the mechano microenvironment and liver cancer stem cells a promising therapeutic strategy for liver cancer |
| topic | liver cancer mechano-microenvironment cancer stem cells tumor heterogeneity mechanotherapy |
| url | https://www.cancerbiomed.org/content/20/11/816 |
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