The role of hemoglobin in nitric oxide transport in vascular system
Nitric oxide (NO) plays a pivotal role in vascular homeostasis and its functions practice in a dose-dependent manner in which too high and too low NO concentration may both induce the development of cardiovascular diseases, which indicates the balance between NO formation and scavenging is critical....
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-03-01
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| Series: | Medicine in Novel Technology and Devices |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590093520300084 |
| _version_ | 1818516469164539904 |
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| author | Haoran Su Xiao Liu Jing Du Xiaoyan Deng Yubo Fan |
| author_facet | Haoran Su Xiao Liu Jing Du Xiaoyan Deng Yubo Fan |
| author_sort | Haoran Su |
| collection | DOAJ |
| description | Nitric oxide (NO) plays a pivotal role in vascular homeostasis and its functions practice in a dose-dependent manner in which too high and too low NO concentration may both induce the development of cardiovascular diseases, which indicates the balance between NO formation and scavenging is critical. Evidence presented over the last two decades has indicated hemoglobin (Hb) can affect NO dynamic equilibrium. The role of Hb was once thought to play in NO signaling as inhibiting NO transport, but now several mechanisms have found that Hb may preserve and even regulate NO activity. Despite the tremendous amount of work devoted to this field, major questions concerning precise mechanisms of NO activity preservation as well as if and how Hb creates NO activity remain unanswered. In this review, we discuss the role of hemoglobin in NO formation, transport and consumption. We also discuss how these mechanisms of the imbalance between NO and hemoglobin induce related diseases, which may serve as the basis for novel therapeutics. |
| first_indexed | 2024-12-11T00:42:41Z |
| format | Article |
| id | doaj.art-02534ff8cffe4d0d8264c56d669e328b |
| institution | Directory Open Access Journal |
| issn | 2590-0935 |
| language | English |
| last_indexed | 2024-12-11T00:42:41Z |
| publishDate | 2020-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Medicine in Novel Technology and Devices |
| spelling | doaj.art-02534ff8cffe4d0d8264c56d669e328b2022-12-22T01:26:51ZengElsevierMedicine in Novel Technology and Devices2590-09352020-03-015The role of hemoglobin in nitric oxide transport in vascular systemHaoran Su0Xiao Liu1Jing Du2Xiaoyan Deng3Yubo Fan4Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, Institute of Nanotechnology for Single Cell Analysis, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, ChinaCorresponding author. School of Biological Science & Medical Engineering, Beihang University, Beijing, 100191, China.; Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, Institute of Nanotechnology for Single Cell Analysis, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, ChinaKey Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, Institute of Nanotechnology for Single Cell Analysis, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, ChinaCorresponding author. School of Biological Science & Medical Engineering, Beihang University, Beijing, 100191, China.; Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, Institute of Nanotechnology for Single Cell Analysis, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, ChinaCorresponding author. School of Biological Science & Medical Engineering, Beihang University, Beijing, 100191, China.; Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, Institute of Nanotechnology for Single Cell Analysis, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, ChinaNitric oxide (NO) plays a pivotal role in vascular homeostasis and its functions practice in a dose-dependent manner in which too high and too low NO concentration may both induce the development of cardiovascular diseases, which indicates the balance between NO formation and scavenging is critical. Evidence presented over the last two decades has indicated hemoglobin (Hb) can affect NO dynamic equilibrium. The role of Hb was once thought to play in NO signaling as inhibiting NO transport, but now several mechanisms have found that Hb may preserve and even regulate NO activity. Despite the tremendous amount of work devoted to this field, major questions concerning precise mechanisms of NO activity preservation as well as if and how Hb creates NO activity remain unanswered. In this review, we discuss the role of hemoglobin in NO formation, transport and consumption. We also discuss how these mechanisms of the imbalance between NO and hemoglobin induce related diseases, which may serve as the basis for novel therapeutics.http://www.sciencedirect.com/science/article/pii/S2590093520300084HemoglobinNitric oxideTransportBalanceDiseases |
| spellingShingle | Haoran Su Xiao Liu Jing Du Xiaoyan Deng Yubo Fan The role of hemoglobin in nitric oxide transport in vascular system Medicine in Novel Technology and Devices Hemoglobin Nitric oxide Transport Balance Diseases |
| title | The role of hemoglobin in nitric oxide transport in vascular system |
| title_full | The role of hemoglobin in nitric oxide transport in vascular system |
| title_fullStr | The role of hemoglobin in nitric oxide transport in vascular system |
| title_full_unstemmed | The role of hemoglobin in nitric oxide transport in vascular system |
| title_short | The role of hemoglobin in nitric oxide transport in vascular system |
| title_sort | role of hemoglobin in nitric oxide transport in vascular system |
| topic | Hemoglobin Nitric oxide Transport Balance Diseases |
| url | http://www.sciencedirect.com/science/article/pii/S2590093520300084 |
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