Restoration of Osteogenesis by CRISPR/Cas9 Genome Editing of the Mutated <i>COL1A1</i> Gene in Osteogenesis Imperfecta

Restoration of Osteogenesis by CRISPR/Cas9 Genome Editing of the Mutated <i>COL1A1</i> Gene in Osteogenesis Imperfecta

Osteogenesis imperfecta (OI) is a genetic disease characterized by bone fragility and repeated fractures. The bone fragility associated with OI is caused by a defect in collagen formation due to mutation of <i>COL1A1</i> or <i>COL1A2</i>. Current strategies for treating OI ar...

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Bibliographic Details
Main Authors: Hyerin Jung, Yeri Alice Rim, Narae Park, Yoojun Nam, Ji Hyeon Ju
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Journal of Clinical Medicine
Subjects:
osteogenesis imperfecta
osteoblast differentiation
induced pluripotent stem cell
<i>COL1A1</i>
gene editing
Online Access:https://www.mdpi.com/2077-0383/10/14/3141

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