Efficacy of phase 3 trial of RTS, S/AS01 malaria vaccine: The need for an alternative development plan
Although vaccines would be the ideal tool for control, prevention, elimination, and eradication of many infectious diseases, developing of parasites vaccines such as malaria vaccine is very complex. The most advanced malaria vaccine candidate RTS,S, a pre-erythrocytic vaccine, has been recommended f...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-09-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2017.1295906 |
| _version_ | 1797677588193214464 |
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| author | Shima Mahmoudi Hossein Keshavarz |
| author_facet | Shima Mahmoudi Hossein Keshavarz |
| author_sort | Shima Mahmoudi |
| collection | DOAJ |
| description | Although vaccines would be the ideal tool for control, prevention, elimination, and eradication of many infectious diseases, developing of parasites vaccines such as malaria vaccine is very complex. The most advanced malaria vaccine candidate RTS,S, a pre-erythrocytic vaccine, has been recommended for licensure by EMEA. The results of this phase III trial suggest that this candidate malaria vaccine has relatively little efficacy, and the vaccine apparently will not meet the goal of malaria eradication by itself. Since there are many vaccine candidates in the pipeline that are being evaluated in vaccine trials, further study on using of alternative parasite targets and vaccination strategies are highly recommended. |
| first_indexed | 2024-03-11T22:47:25Z |
| format | Article |
| id | doaj.art-025654338dc446249fe7af22abcee088 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:47:25Z |
| publishDate | 2017-09-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-025654338dc446249fe7af22abcee0882023-09-22T08:17:49ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2017-09-011392098210110.1080/21645515.2017.12959061295906Efficacy of phase 3 trial of RTS, S/AS01 malaria vaccine: The need for an alternative development planShima Mahmoudi0Hossein Keshavarz1Tehran University of Medical ScienceTehran University of Medical SciencesAlthough vaccines would be the ideal tool for control, prevention, elimination, and eradication of many infectious diseases, developing of parasites vaccines such as malaria vaccine is very complex. The most advanced malaria vaccine candidate RTS,S, a pre-erythrocytic vaccine, has been recommended for licensure by EMEA. The results of this phase III trial suggest that this candidate malaria vaccine has relatively little efficacy, and the vaccine apparently will not meet the goal of malaria eradication by itself. Since there are many vaccine candidates in the pipeline that are being evaluated in vaccine trials, further study on using of alternative parasite targets and vaccination strategies are highly recommended.http://dx.doi.org/10.1080/21645515.2017.1295906efficacyrtss/as01 malaria vaccinevaccine development |
| spellingShingle | Shima Mahmoudi Hossein Keshavarz Efficacy of phase 3 trial of RTS, S/AS01 malaria vaccine: The need for an alternative development plan Human Vaccines & Immunotherapeutics efficacy rts s/as01 malaria vaccine vaccine development |
| title | Efficacy of phase 3 trial of RTS, S/AS01 malaria vaccine: The need for an alternative development plan |
| title_full | Efficacy of phase 3 trial of RTS, S/AS01 malaria vaccine: The need for an alternative development plan |
| title_fullStr | Efficacy of phase 3 trial of RTS, S/AS01 malaria vaccine: The need for an alternative development plan |
| title_full_unstemmed | Efficacy of phase 3 trial of RTS, S/AS01 malaria vaccine: The need for an alternative development plan |
| title_short | Efficacy of phase 3 trial of RTS, S/AS01 malaria vaccine: The need for an alternative development plan |
| title_sort | efficacy of phase 3 trial of rts s as01 malaria vaccine the need for an alternative development plan |
| topic | efficacy rts s/as01 malaria vaccine vaccine development |
| url | http://dx.doi.org/10.1080/21645515.2017.1295906 |
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