Involvement of vascular endothelial growth factor in nasal obstruction in patients with nasal allergy
It has recently been shown that vascular endothelial growth factor (VEGF) enhances vascular permeability and that mast cells produce VEGF, suggesting the involvement of VEGF in allergic diseases. In the present study we quantitatively analyzed VEGF in the nasal lavage fluid of patients with nasal al...
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| Format: | Article |
| Language: | English |
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Elsevier
2000-01-01
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| Series: | Allergology International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893015314040 |
| _version_ | 1818272489357180928 |
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| author | Tetsuji Yamashita Nobuhisa Terada Nanako Hamano Hirohisa Kishi Noriko Kobayashi Yukiko Kotani Masakazu Miura Akiyoshi Konno |
| author_facet | Tetsuji Yamashita Nobuhisa Terada Nanako Hamano Hirohisa Kishi Noriko Kobayashi Yukiko Kotani Masakazu Miura Akiyoshi Konno |
| author_sort | Tetsuji Yamashita |
| collection | DOAJ |
| description | It has recently been shown that vascular endothelial growth factor (VEGF) enhances vascular permeability and that mast cells produce VEGF, suggesting the involvement of VEGF in allergic diseases. In the present study we quantitatively analyzed VEGF in the nasal lavage fluid of patients with nasal allergy. We performed nasal antigen challenge with Japanese cedar pollen antigen in 10 healthy adult volunteers and in 10 cedar pollen IgE-positive patients with nasal allergy. In all patients with nasal allergy, VEGF and histamine levels in the nasal lavage fluid reached a peak 30 min after antigen challenge, then returned to prechallenge values 2 h after antigen challenge. In these patients, the histamine level increased three-fold, while the VEGF level increased 10-fold. However, in all healthy adult volunteers, VEGF and histamine levels did not increase. A stronger correlation was noted between the ratio of decreased nasal cavity volume and the ratio of increased VEGF levels (R = 0.823; P < 0.001) than between the ratio of nasal cavity volume and the ratio of increased histamine levels (R = 0.660; P < 0.01). These results suggest that VEGF may contribute to the pathogenesis of nasal obstruction in the early phase of nasal allergy as a new factor involved in increasing vascular permeability. |
| first_indexed | 2024-12-12T21:42:53Z |
| format | Article |
| id | doaj.art-025726709168462c852ed5a426456abf |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-12-12T21:42:53Z |
| publishDate | 2000-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-025726709168462c852ed5a426456abf2022-12-22T00:10:59ZengElsevierAllergology International1323-89302000-01-0149318318810.1046/j.1440-1592.2000.00178.xInvolvement of vascular endothelial growth factor in nasal obstruction in patients with nasal allergyTetsuji Yamashita0Nobuhisa Terada1Nanako Hamano2Hirohisa Kishi3Noriko Kobayashi4Yukiko Kotani5Masakazu Miura6Akiyoshi Konno7R&D Mitsubishi Kagaku Bio-clinical Laboratories Inc., Tokyo, JapanDepartment of Otorhinolaryngology, Chiba University, School of Medicine, Chiba, JapanDepartment of Otorhinolaryngology, Chiba University, School of Medicine, Chiba, JapanDepartment of Otorhinolaryngology, Chiba University, School of Medicine, Chiba, JapanDepartment of Otorhinolaryngology, Chiba University, School of Medicine, Chiba, JapanR&D Mitsubishi Kagaku Bio-clinical Laboratories Inc., Tokyo, JapanR&D Mitsubishi Kagaku Bio-clinical Laboratories Inc., Tokyo, JapanDepartment of Otorhinolaryngology, Chiba University, School of Medicine, Chiba, JapanIt has recently been shown that vascular endothelial growth factor (VEGF) enhances vascular permeability and that mast cells produce VEGF, suggesting the involvement of VEGF in allergic diseases. In the present study we quantitatively analyzed VEGF in the nasal lavage fluid of patients with nasal allergy. We performed nasal antigen challenge with Japanese cedar pollen antigen in 10 healthy adult volunteers and in 10 cedar pollen IgE-positive patients with nasal allergy. In all patients with nasal allergy, VEGF and histamine levels in the nasal lavage fluid reached a peak 30 min after antigen challenge, then returned to prechallenge values 2 h after antigen challenge. In these patients, the histamine level increased three-fold, while the VEGF level increased 10-fold. However, in all healthy adult volunteers, VEGF and histamine levels did not increase. A stronger correlation was noted between the ratio of decreased nasal cavity volume and the ratio of increased VEGF levels (R = 0.823; P < 0.001) than between the ratio of nasal cavity volume and the ratio of increased histamine levels (R = 0.660; P < 0.01). These results suggest that VEGF may contribute to the pathogenesis of nasal obstruction in the early phase of nasal allergy as a new factor involved in increasing vascular permeability.http://www.sciencedirect.com/science/article/pii/S1323893015314040mast cellsnasal allergynasal antigen challenge testnasal obstructionvascular endothelial growth factorvascular permeability |
| spellingShingle | Tetsuji Yamashita Nobuhisa Terada Nanako Hamano Hirohisa Kishi Noriko Kobayashi Yukiko Kotani Masakazu Miura Akiyoshi Konno Involvement of vascular endothelial growth factor in nasal obstruction in patients with nasal allergy Allergology International mast cells nasal allergy nasal antigen challenge test nasal obstruction vascular endothelial growth factor vascular permeability |
| title | Involvement of vascular endothelial growth factor in nasal obstruction in patients with nasal allergy |
| title_full | Involvement of vascular endothelial growth factor in nasal obstruction in patients with nasal allergy |
| title_fullStr | Involvement of vascular endothelial growth factor in nasal obstruction in patients with nasal allergy |
| title_full_unstemmed | Involvement of vascular endothelial growth factor in nasal obstruction in patients with nasal allergy |
| title_short | Involvement of vascular endothelial growth factor in nasal obstruction in patients with nasal allergy |
| title_sort | involvement of vascular endothelial growth factor in nasal obstruction in patients with nasal allergy |
| topic | mast cells nasal allergy nasal antigen challenge test nasal obstruction vascular endothelial growth factor vascular permeability |
| url | http://www.sciencedirect.com/science/article/pii/S1323893015314040 |
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