Loganin Alleviates Gout Inflammation by Suppressing NLRP3 Inflammasome Activation and Mitochondrial Damage

Loganin Alleviates Gout Inflammation by Suppressing NLRP3 Inflammasome Activation and Mitochondrial Damage

Gout is a type of inflammatory arthritis caused by the deposition of monosodium uric acid (MSU) crystals in tissues. The etiology of gout is directly linked to the NLRP3 inflammasome, since MSU crystals are NLRP3 inflammasome activators. Therefore, we decided to search for a small-molecule inhibitor...

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Bibliographic Details
Main Authors: Nuri Choi, Gabsik Yang, Joo Hyeon Jang, Han Chang Kang, Yong-Yeon Cho, Hye Suk Lee, Joo Young Lee
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Molecules
Subjects:
innate immunity
inflammation
pharmacological inhibitor
mitochondria
cytokine
Online Access:https://www.mdpi.com/1420-3049/26/4/1071

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