Association of tear fluid amyloid and tau levels with disease severity and neurodegeneration
Abstract There has been increasing interest in finding non-invasive biomarkers for neurodegenerative diseases such as Alzheimer’s disease (AD). This observational study investigated AD-specific biomarkers in tear fluid. Tear fluid was collected from a total of 65 subjects, including 23 patients with...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-01993-x |
| _version_ | 1818433817708331008 |
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| author | Marlies Gijs Inez H. G. B. Ramakers Pieter Jelle Visser Frans R. J. Verhey Marjo P. H. van de Waarenburg Casper G. Schalkwijk Rudy M. M. A. Nuijts Carroll A. B. Webers |
| author_facet | Marlies Gijs Inez H. G. B. Ramakers Pieter Jelle Visser Frans R. J. Verhey Marjo P. H. van de Waarenburg Casper G. Schalkwijk Rudy M. M. A. Nuijts Carroll A. B. Webers |
| author_sort | Marlies Gijs |
| collection | DOAJ |
| description | Abstract There has been increasing interest in finding non-invasive biomarkers for neurodegenerative diseases such as Alzheimer’s disease (AD). This observational study investigated AD-specific biomarkers in tear fluid. Tear fluid was collected from a total of 65 subjects, including 23 patients with subjective cognitive decline (SCD), 22 patients with mild cognitive impairment (MCI), 11 dementia patients and 9 healthy controls (HC). Levels of amyloid-beta peptides (AB38, AB40, AB42), total-tau (t-tau) and phosphorylated-tau (p-tau) were determined using multiplex immunoassays. Levels of AB40 and t-tau were detectable in the vast majority (> 94%) of tear fluid samples. Cerebrospinal fluid (CSF) was available from a subset of patients. In this group, tear t-tau levels were significantly higher in people with dementia compared to SCD patients. Tear t-tau levels were elevated in patients with neurodegeneration (classified according to the A/T/N system) compared to patients without neurodegeneration. Negative correlations were found between CSF AB42 and CSF t-tau, and between CSF AB42 and tear t-tau. In summary, this study shows the potential of tau proteins in tear fluid to be associated with disease severity and neurodegeneration. |
| first_indexed | 2024-12-14T16:27:08Z |
| format | Article |
| id | doaj.art-0259775b371840b5a3af84478f3ec598 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T16:27:08Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-0259775b371840b5a3af84478f3ec5982022-12-21T22:54:39ZengNature PortfolioScientific Reports2045-23222021-11-011111810.1038/s41598-021-01993-xAssociation of tear fluid amyloid and tau levels with disease severity and neurodegenerationMarlies Gijs0Inez H. G. B. Ramakers1Pieter Jelle Visser2Frans R. J. Verhey3Marjo P. H. van de Waarenburg4Casper G. Schalkwijk5Rudy M. M. A. Nuijts6Carroll A. B. Webers7University Eye Clinic Maastricht, Maastricht University Medical Center (MUMC+), School for Mental Health and Neuroscience, Maastricht UniversityDepartment of Psychiatry and Neuropsychology, Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht UniversityDepartment of Psychiatry and Neuropsychology, Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht UniversityDepartment of Psychiatry and Neuropsychology, Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht UniversityDepartment of Internal Medicine, School for Cardiovascular Diseases (CARIM), Maastricht University Medical CenterDepartment of Internal Medicine, School for Cardiovascular Diseases (CARIM), Maastricht University Medical CenterUniversity Eye Clinic Maastricht, Maastricht University Medical Center (MUMC+), School for Mental Health and Neuroscience, Maastricht UniversityUniversity Eye Clinic Maastricht, Maastricht University Medical Center (MUMC+), School for Mental Health and Neuroscience, Maastricht UniversityAbstract There has been increasing interest in finding non-invasive biomarkers for neurodegenerative diseases such as Alzheimer’s disease (AD). This observational study investigated AD-specific biomarkers in tear fluid. Tear fluid was collected from a total of 65 subjects, including 23 patients with subjective cognitive decline (SCD), 22 patients with mild cognitive impairment (MCI), 11 dementia patients and 9 healthy controls (HC). Levels of amyloid-beta peptides (AB38, AB40, AB42), total-tau (t-tau) and phosphorylated-tau (p-tau) were determined using multiplex immunoassays. Levels of AB40 and t-tau were detectable in the vast majority (> 94%) of tear fluid samples. Cerebrospinal fluid (CSF) was available from a subset of patients. In this group, tear t-tau levels were significantly higher in people with dementia compared to SCD patients. Tear t-tau levels were elevated in patients with neurodegeneration (classified according to the A/T/N system) compared to patients without neurodegeneration. Negative correlations were found between CSF AB42 and CSF t-tau, and between CSF AB42 and tear t-tau. In summary, this study shows the potential of tau proteins in tear fluid to be associated with disease severity and neurodegeneration.https://doi.org/10.1038/s41598-021-01993-x |
| spellingShingle | Marlies Gijs Inez H. G. B. Ramakers Pieter Jelle Visser Frans R. J. Verhey Marjo P. H. van de Waarenburg Casper G. Schalkwijk Rudy M. M. A. Nuijts Carroll A. B. Webers Association of tear fluid amyloid and tau levels with disease severity and neurodegeneration Scientific Reports |
| title | Association of tear fluid amyloid and tau levels with disease severity and neurodegeneration |
| title_full | Association of tear fluid amyloid and tau levels with disease severity and neurodegeneration |
| title_fullStr | Association of tear fluid amyloid and tau levels with disease severity and neurodegeneration |
| title_full_unstemmed | Association of tear fluid amyloid and tau levels with disease severity and neurodegeneration |
| title_short | Association of tear fluid amyloid and tau levels with disease severity and neurodegeneration |
| title_sort | association of tear fluid amyloid and tau levels with disease severity and neurodegeneration |
| url | https://doi.org/10.1038/s41598-021-01993-x |
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