Mechanism of biofilm formation in ESKAPE organism and their treatment
One of the major global issues is the urgency of nosocomial infections, biofilm development, and antibiotic resistance. The ESKAPE pathogens are a significant factor in these problems (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2022-12-01
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| Series: | Romanian Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | https://rjid.com.ro/articles/2022.4/RJID_2022_4_Art-03.pdf |
| _version_ | 1797745023873187840 |
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| author | Apoorva Jain Palaksha Kanive Javaregowda Sughosh S Kulkarni Raghavendra D Kulkarni Kelmani Chandrakanth R Ajay Kumar Oli |
| author_facet | Apoorva Jain Palaksha Kanive Javaregowda Sughosh S Kulkarni Raghavendra D Kulkarni Kelmani Chandrakanth R Ajay Kumar Oli |
| author_sort | Apoorva Jain |
| collection | DOAJ |
| description | One of the major global issues is the urgency of nosocomial infections, biofilm development, and antibiotic resistance. The ESKAPE pathogens are a significant factor in these problems (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species).
These pathogens, often known as hospital-acquired infections (HAIs), are common in hospital settings and present one of the most significant difficulties in treatment. The development of biofilms, in which the microbial cells adapt to a multicellular lifestyle by getting trapped inside the extracellular polymeric matrix, is a key biological concept in clinical contexts. For the creation of novel antimicrobial agents, as well as for the repurposing of currently accessible medications or pre-clinical substances and the broader use of combination therapies, it is essential to comprehend the process by which these bacteria build biofilms. The Pathomechanisms of these bacterial biofilm formations and alternate strategies to prevent biofilm formation in hospital management are highlighted in this review. |
| first_indexed | 2024-03-12T15:18:30Z |
| format | Article |
| id | doaj.art-0259aec8ab5049b2ae0d6d0234e8add6 |
| institution | Directory Open Access Journal |
| issn | 1454-3389 2069-6051 |
| language | English |
| last_indexed | 2024-03-12T15:18:30Z |
| publishDate | 2022-12-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Infectious Diseases |
| spelling | doaj.art-0259aec8ab5049b2ae0d6d0234e8add62023-08-11T08:51:23ZengAmaltea Medical Publishing HouseRomanian Journal of Infectious Diseases1454-33892069-60512022-12-012549710710.37897/RJID.2022.4.3Mechanism of biofilm formation in ESKAPE organism and their treatmentApoorva Jain0Palaksha Kanive Javaregowda1Sughosh S Kulkarni2Raghavendra D Kulkarni3Kelmani Chandrakanth R4 Ajay Kumar Oli5Department of Biomedical Science, SDM Research Institute for Biomedical Sciences, Shri Dharmasthala Manjunatheshwara University, Sattur, Dharwad, Karnataka, IndiaDepartment of Biomedical Science, SDM Research Institute for Biomedical Sciences, Shri Dharmasthala Manjunatheshwara University, Sattur, Dharwad, Karnataka, IndiaDepartment of Microbiology, SDM College of Medical Sciences and Hospital, Shri Dharmasthala Manjunatheshwara University, Sattur, Dharwad, Karnataka, IndiaDepartment of Microbiology, SDM College of Medical Sciences and Hospital, Shri Dharmasthala Manjunatheshwara University, Sattur, Dharwad, Karnataka, IndiaDepartment of Biotechnology, Jnana Ganga Campus, Gulbarga University, Kalaburagi, Karnataka, IndiaDepartment of Biomedical Science, SDM Research Institute for Biomedical Sciences, Shri Dharmasthala Manjunatheshwara University, Sattur, Dharwad, Karnataka, IndiaOne of the major global issues is the urgency of nosocomial infections, biofilm development, and antibiotic resistance. The ESKAPE pathogens are a significant factor in these problems (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species). These pathogens, often known as hospital-acquired infections (HAIs), are common in hospital settings and present one of the most significant difficulties in treatment. The development of biofilms, in which the microbial cells adapt to a multicellular lifestyle by getting trapped inside the extracellular polymeric matrix, is a key biological concept in clinical contexts. For the creation of novel antimicrobial agents, as well as for the repurposing of currently accessible medications or pre-clinical substances and the broader use of combination therapies, it is essential to comprehend the process by which these bacteria build biofilms. The Pathomechanisms of these bacterial biofilm formations and alternate strategies to prevent biofilm formation in hospital management are highlighted in this review.https://rjid.com.ro/articles/2022.4/RJID_2022_4_Art-03.pdfeskapebiofilm formationhaisextracellular matrixtherapies |
| spellingShingle | Apoorva Jain Palaksha Kanive Javaregowda Sughosh S Kulkarni Raghavendra D Kulkarni Kelmani Chandrakanth R Ajay Kumar Oli Mechanism of biofilm formation in ESKAPE organism and their treatment Romanian Journal of Infectious Diseases eskape biofilm formation hais extracellular matrix therapies |
| title | Mechanism of biofilm formation in ESKAPE organism and their treatment |
| title_full | Mechanism of biofilm formation in ESKAPE organism and their treatment |
| title_fullStr | Mechanism of biofilm formation in ESKAPE organism and their treatment |
| title_full_unstemmed | Mechanism of biofilm formation in ESKAPE organism and their treatment |
| title_short | Mechanism of biofilm formation in ESKAPE organism and their treatment |
| title_sort | mechanism of biofilm formation in eskape organism and their treatment |
| topic | eskape biofilm formation hais extracellular matrix therapies |
| url | https://rjid.com.ro/articles/2022.4/RJID_2022_4_Art-03.pdf |
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