Phyto-Carbazole Alkaloids from the Rutaceae Family as Potential Protective Agents against Neurodegenerative Diseases
Plant-derived (phyto) carbazole alkaloids are an important class of compounds, presented in the family of Rutaceae (Genera <i>Murraya</i>, <i>Clausena</i>, <i>Glycosmis</i>, <i>Micromelum</i> and <i>Zanthoxylum</i>). Due to several signific...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/3/493 |
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| author | Mario A. Tan Niti Sharma Seong Soo A. An |
| author_facet | Mario A. Tan Niti Sharma Seong Soo A. An |
| author_sort | Mario A. Tan |
| collection | DOAJ |
| description | Plant-derived (phyto) carbazole alkaloids are an important class of compounds, presented in the family of Rutaceae (Genera <i>Murraya</i>, <i>Clausena</i>, <i>Glycosmis</i>, <i>Micromelum</i> and <i>Zanthoxylum</i>). Due to several significant biological activities, such as antitumor, antibacterial, antiviral, antidiabetic, anti-HIV and neuroprotective activities of the parent skeleton (3-methylcarbazole), carbazole alkaloids are recognized as an important class of potential therapeutic agents. Neurodegenerative diseases (NDs) may exhibit a vast range of conditions, affecting neurons primarily and leading ultimately to the progressive losses of normal motor and cognitive functions. The main pathophysiological indicators of NDs comprise increasing atypical protein folding, oxidative stresses, mitochondrial dysfunctions, deranged neurotransmissions and neuronal losses. Phyto-carbazole alkaloids can be investigated for exerting multitarget approaches to ameliorating NDs. This review presents a comprehensive evaluation of the available scientific literature on the neuroprotective mechanisms of phyto-carbazole alkaloids from the Rutaceae family in ameliorating NDs. |
| first_indexed | 2024-03-09T13:52:40Z |
| format | Article |
| id | doaj.art-0259cf683af3419a9040c5c571ca7bbd |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T13:52:40Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-0259cf683af3419a9040c5c571ca7bbd2023-11-30T20:47:44ZengMDPI AGAntioxidants2076-39212022-03-0111349310.3390/antiox11030493Phyto-Carbazole Alkaloids from the Rutaceae Family as Potential Protective Agents against Neurodegenerative DiseasesMario A. Tan0Niti Sharma1Seong Soo A. An2College of Science and Research Center for the Natural and Applied Sciences, University of Santo Tomas, Manila 1015, PhilippinesDepartment of Bionano Technology, Gachon University, 1342 Seongnam-daero, Sujeong-Gu, Seongnam 461-701, KoreaDepartment of Bionano Technology, Gachon University, 1342 Seongnam-daero, Sujeong-Gu, Seongnam 461-701, KoreaPlant-derived (phyto) carbazole alkaloids are an important class of compounds, presented in the family of Rutaceae (Genera <i>Murraya</i>, <i>Clausena</i>, <i>Glycosmis</i>, <i>Micromelum</i> and <i>Zanthoxylum</i>). Due to several significant biological activities, such as antitumor, antibacterial, antiviral, antidiabetic, anti-HIV and neuroprotective activities of the parent skeleton (3-methylcarbazole), carbazole alkaloids are recognized as an important class of potential therapeutic agents. Neurodegenerative diseases (NDs) may exhibit a vast range of conditions, affecting neurons primarily and leading ultimately to the progressive losses of normal motor and cognitive functions. The main pathophysiological indicators of NDs comprise increasing atypical protein folding, oxidative stresses, mitochondrial dysfunctions, deranged neurotransmissions and neuronal losses. Phyto-carbazole alkaloids can be investigated for exerting multitarget approaches to ameliorating NDs. This review presents a comprehensive evaluation of the available scientific literature on the neuroprotective mechanisms of phyto-carbazole alkaloids from the Rutaceae family in ameliorating NDs.https://www.mdpi.com/2076-3921/11/3/493neurodegenerative diseaseRutaceaephyto carbazole alkaloidoxidative stressneuroinflammationAlzheimer’s disease |
| spellingShingle | Mario A. Tan Niti Sharma Seong Soo A. An Phyto-Carbazole Alkaloids from the Rutaceae Family as Potential Protective Agents against Neurodegenerative Diseases Antioxidants neurodegenerative disease Rutaceae phyto carbazole alkaloid oxidative stress neuroinflammation Alzheimer’s disease |
| title | Phyto-Carbazole Alkaloids from the Rutaceae Family as Potential Protective Agents against Neurodegenerative Diseases |
| title_full | Phyto-Carbazole Alkaloids from the Rutaceae Family as Potential Protective Agents against Neurodegenerative Diseases |
| title_fullStr | Phyto-Carbazole Alkaloids from the Rutaceae Family as Potential Protective Agents against Neurodegenerative Diseases |
| title_full_unstemmed | Phyto-Carbazole Alkaloids from the Rutaceae Family as Potential Protective Agents against Neurodegenerative Diseases |
| title_short | Phyto-Carbazole Alkaloids from the Rutaceae Family as Potential Protective Agents against Neurodegenerative Diseases |
| title_sort | phyto carbazole alkaloids from the rutaceae family as potential protective agents against neurodegenerative diseases |
| topic | neurodegenerative disease Rutaceae phyto carbazole alkaloid oxidative stress neuroinflammation Alzheimer’s disease |
| url | https://www.mdpi.com/2076-3921/11/3/493 |
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