Neoatherosclerosis: A Distinctive Pathological Mechanism of Stent Failure
With the development of drug-eluting stents, intimal re-endothelialisation is significantly inhibited by antiproliferative drugs, and stent restenosis transforms from smooth muscle cell proliferation to neoatherosclerosis (NA). As a result of the development of intravascular imaging technology, the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2024-03-01
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| Series: | Reviews in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/RCM/25/3/10.31083/j.rcm2503095 |
| _version_ | 1797238658633302016 |
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| author | Mengting Jiang Yu Zhang Yan Han Xiaohang Yuan Lei Gao |
| author_facet | Mengting Jiang Yu Zhang Yan Han Xiaohang Yuan Lei Gao |
| author_sort | Mengting Jiang |
| collection | DOAJ |
| description | With the development of drug-eluting stents, intimal re-endothelialisation is significantly inhibited by antiproliferative drugs, and stent restenosis transforms from smooth muscle cell proliferation to neoatherosclerosis (NA). As a result of the development of intravascular imaging technology, the incidence and characteristics of NA can be explored in vivo, with some progress made in illustrating the mechanisms of NA. Experimental studies have shed light on the molecular characteristics of NA. More critically, sufficient evidence proves NA as a significant cause of late stent failure. Treatments for NA are still being explored. In this review, we summarise the histopathological characteristics of different types of stent NA, explore the potential relationship of NA with native atherosclerosis and discuss the clinical significance of NA in late stent failure and the promising present and future prevention and treatment strategies. |
| first_indexed | 2024-04-24T17:39:09Z |
| format | Article |
| id | doaj.art-0259d75f56cf43519b2ea27eea23eb16 |
| institution | Directory Open Access Journal |
| issn | 1530-6550 |
| language | English |
| last_indexed | 2024-04-24T17:39:09Z |
| publishDate | 2024-03-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Reviews in Cardiovascular Medicine |
| spelling | doaj.art-0259d75f56cf43519b2ea27eea23eb162024-03-28T01:50:31ZengIMR PressReviews in Cardiovascular Medicine1530-65502024-03-012539510.31083/j.rcm2503095S1530-6550(23)01231-0Neoatherosclerosis: A Distinctive Pathological Mechanism of Stent FailureMengting Jiang0Yu Zhang1Yan Han2Xiaohang Yuan3Lei Gao4Senior Department of Cardiology, Sixth Medical Center of Chinese PLA General Hospital, 100048 Beijing, ChinaDepartment of Clinical Training and Teaching, Tianjin University of Traditional Chinese Medicine, 301617 Tianjin, ChinaSenior Department of Cardiology, Sixth Medical Center of Chinese PLA General Hospital, 100048 Beijing, ChinaSenior Department of Cardiology, Sixth Medical Center of Chinese PLA General Hospital, 100048 Beijing, ChinaSenior Department of Cardiology, Sixth Medical Center of Chinese PLA General Hospital, 100048 Beijing, ChinaWith the development of drug-eluting stents, intimal re-endothelialisation is significantly inhibited by antiproliferative drugs, and stent restenosis transforms from smooth muscle cell proliferation to neoatherosclerosis (NA). As a result of the development of intravascular imaging technology, the incidence and characteristics of NA can be explored in vivo, with some progress made in illustrating the mechanisms of NA. Experimental studies have shed light on the molecular characteristics of NA. More critically, sufficient evidence proves NA as a significant cause of late stent failure. Treatments for NA are still being explored. In this review, we summarise the histopathological characteristics of different types of stent NA, explore the potential relationship of NA with native atherosclerosis and discuss the clinical significance of NA in late stent failure and the promising present and future prevention and treatment strategies.https://www.imrpress.com/journal/RCM/25/3/10.31083/j.rcm2503095neoatherosclerosisin-stent restenosisoptical coherence tomographyvery late stent thrombosisatherosclerosis |
| spellingShingle | Mengting Jiang Yu Zhang Yan Han Xiaohang Yuan Lei Gao Neoatherosclerosis: A Distinctive Pathological Mechanism of Stent Failure Reviews in Cardiovascular Medicine neoatherosclerosis in-stent restenosis optical coherence tomography very late stent thrombosis atherosclerosis |
| title | Neoatherosclerosis: A Distinctive Pathological Mechanism of Stent Failure |
| title_full | Neoatherosclerosis: A Distinctive Pathological Mechanism of Stent Failure |
| title_fullStr | Neoatherosclerosis: A Distinctive Pathological Mechanism of Stent Failure |
| title_full_unstemmed | Neoatherosclerosis: A Distinctive Pathological Mechanism of Stent Failure |
| title_short | Neoatherosclerosis: A Distinctive Pathological Mechanism of Stent Failure |
| title_sort | neoatherosclerosis a distinctive pathological mechanism of stent failure |
| topic | neoatherosclerosis in-stent restenosis optical coherence tomography very late stent thrombosis atherosclerosis |
| url | https://www.imrpress.com/journal/RCM/25/3/10.31083/j.rcm2503095 |
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