25-hydroxyvitamin D level is associated with greater grip strength across adult life span: a population-based cohort study
Objective: Maintaining muscle function throughout life is critical for healthy ageing. Although in vitro studies consistently indicate beneficial effects of 25-hydroxyvitamin D (25-OHD) on muscle function, findings from population-based studies remain inconclusive. We therefore aimed to examine the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Bioscientifica
2023-04-01
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| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://ec.bioscientifica.com/view/journals/ec/12/4/EC-22-0501.xml |
| _version_ | 1797851621223301120 |
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| author | Fabienne A U Fox Lennart Koch Monique M B Breteler N Ahmad Aziz |
| author_facet | Fabienne A U Fox Lennart Koch Monique M B Breteler N Ahmad Aziz |
| author_sort | Fabienne A U Fox |
| collection | DOAJ |
| description | Objective: Maintaining muscle function throughout life is critical for healthy ageing. Although in vitro studies consistently indicate beneficial effects of 25-hydroxyvitamin D (25-OHD) on muscle function, findings from population-based studies remain inconclusive. We therefore aimed to examine the association between 25-OHD concentration and handgrip strength across a wide age range and assess potential modifying effects of age, sex and season.
Methods: We analysed cross-sectional baseline data of 2576 eligible participants out of the first 3000 participants (recruited from March 2016 to March 2019) of the Rhineland Study, a community-based cohort study in Bonn, Germany. Multivariate linear regression models were used to assess the relation between 25-OHD levels and grip strength while adjusting for age, sex, education, smoking, season, body mass index, physical activity levels, osteoporosis and vitamin D supplementation.
Results: Compared to participants with deficient 25-OHD levels (<30 nmol/L), grip strength was higher in those with inadequate (30 to <50 nmol/L) and adequate (≥50 to ≤125 nmol/L) levels (ßinadequate = 1.222, 95% CI: 0.377; 2.067, P = 0.005; ßadequate = 1.228, 95% CI: 0.437; 2.019, P = 0.002). Modelling on a continuous scale revealed grip strength to increase with higher 25-OHD levels up to ~100 nmol/L, after which the direction reversed (ßlinear = 0.505, 95% CI: 0.179; 0.830, P = 0.002; ßquadratic = –0.153, 95% CI: –0.269; -0.038, P = 0.009). Older adults showed weaker effects of 25-OHD levels on grip strength than younger adults (ß25OHDxAge = –0.309, 95% CI: –0.594; –0.024, P = 0.033).
Conclusions: Our findings highlight the importance of sufficient 25-OHD levels for optimal muscle function across the adult life span. However, vitamin D supplementation should be closely monitored to avoid detrimental effects. |
| first_indexed | 2024-04-09T19:20:43Z |
| format | Article |
| id | doaj.art-025a7b7c68d84dbb9721b4312bb51826 |
| institution | Directory Open Access Journal |
| issn | 2049-3614 |
| language | English |
| last_indexed | 2024-04-09T19:20:43Z |
| publishDate | 2023-04-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-025a7b7c68d84dbb9721b4312bb518262023-04-05T10:44:10ZengBioscientificaEndocrine Connections2049-36142023-04-01124115https://doi.org/10.1530/EC-22-050125-hydroxyvitamin D level is associated with greater grip strength across adult life span: a population-based cohort studyFabienne A U Fox0Lennart Koch1Monique M B Breteler2N Ahmad Aziz3Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Bonn, GermanyPopulation Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; University for Health Sciences, Medical Informatics and Technology (UMIT TIROL), Tirol, Austria Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Institute for Medical Biometry, Informatics and Epidemiology (IMBIE), Faculty of Medicine, University of Bonn, Bonn, Germany Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department of Neurology, Faculty of Medicine, University of Bonn, Bonn, Germany Objective: Maintaining muscle function throughout life is critical for healthy ageing. Although in vitro studies consistently indicate beneficial effects of 25-hydroxyvitamin D (25-OHD) on muscle function, findings from population-based studies remain inconclusive. We therefore aimed to examine the association between 25-OHD concentration and handgrip strength across a wide age range and assess potential modifying effects of age, sex and season. Methods: We analysed cross-sectional baseline data of 2576 eligible participants out of the first 3000 participants (recruited from March 2016 to March 2019) of the Rhineland Study, a community-based cohort study in Bonn, Germany. Multivariate linear regression models were used to assess the relation between 25-OHD levels and grip strength while adjusting for age, sex, education, smoking, season, body mass index, physical activity levels, osteoporosis and vitamin D supplementation. Results: Compared to participants with deficient 25-OHD levels (<30 nmol/L), grip strength was higher in those with inadequate (30 to <50 nmol/L) and adequate (≥50 to ≤125 nmol/L) levels (ßinadequate = 1.222, 95% CI: 0.377; 2.067, P = 0.005; ßadequate = 1.228, 95% CI: 0.437; 2.019, P = 0.002). Modelling on a continuous scale revealed grip strength to increase with higher 25-OHD levels up to ~100 nmol/L, after which the direction reversed (ßlinear = 0.505, 95% CI: 0.179; 0.830, P = 0.002; ßquadratic = –0.153, 95% CI: –0.269; -0.038, P = 0.009). Older adults showed weaker effects of 25-OHD levels on grip strength than younger adults (ß25OHDxAge = –0.309, 95% CI: –0.594; –0.024, P = 0.033). Conclusions: Our findings highlight the importance of sufficient 25-OHD levels for optimal muscle function across the adult life span. However, vitamin D supplementation should be closely monitored to avoid detrimental effects.https://ec.bioscientifica.com/view/journals/ec/12/4/EC-22-0501.xmlvitamin dgrip strengthsarcopeniamuscle strengthcohort studyageing |
| spellingShingle | Fabienne A U Fox Lennart Koch Monique M B Breteler N Ahmad Aziz 25-hydroxyvitamin D level is associated with greater grip strength across adult life span: a population-based cohort study Endocrine Connections vitamin d grip strength sarcopenia muscle strength cohort study ageing |
| title | 25-hydroxyvitamin D level is associated with greater grip strength across adult life span: a population-based cohort study |
| title_full | 25-hydroxyvitamin D level is associated with greater grip strength across adult life span: a population-based cohort study |
| title_fullStr | 25-hydroxyvitamin D level is associated with greater grip strength across adult life span: a population-based cohort study |
| title_full_unstemmed | 25-hydroxyvitamin D level is associated with greater grip strength across adult life span: a population-based cohort study |
| title_short | 25-hydroxyvitamin D level is associated with greater grip strength across adult life span: a population-based cohort study |
| title_sort | 25 hydroxyvitamin d level is associated with greater grip strength across adult life span a population based cohort study |
| topic | vitamin d grip strength sarcopenia muscle strength cohort study ageing |
| url | https://ec.bioscientifica.com/view/journals/ec/12/4/EC-22-0501.xml |
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