Platelet glycoprotein VI genetic quantitative and qualitative defects
Platelet membrane glycoprotein VI (GPVI) is increasingly recognized as an important receptor for thrombus formation and growth. Numerous arguments have been published indicating that GPVI plays a major role in thrombosis without being essential for physiological hemostasis. In humans, GPVI deficienc...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-08-01
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| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2019.1610166 |
| _version_ | 1827816893034004480 |
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| author | Martine Jandrot-Perrus Cedric Hermans Diego Mezzano |
| author_facet | Martine Jandrot-Perrus Cedric Hermans Diego Mezzano |
| author_sort | Martine Jandrot-Perrus |
| collection | DOAJ |
| description | Platelet membrane glycoprotein VI (GPVI) is increasingly recognized as an important receptor for thrombus formation and growth. Numerous arguments have been published indicating that GPVI plays a major role in thrombosis without being essential for physiological hemostasis. In humans, GPVI deficiencies are rarely reported. These are most often deficiencies occurring in the context of autoimmunity and, more rarely, genetic deficits. The purpose of this review is to compile data on the quantitative and qualitative genetic abnormalities of GPVI. |
| first_indexed | 2024-03-12T00:26:45Z |
| format | Article |
| id | doaj.art-025fa129574f4e269e1a85ff4f209f04 |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:26:45Z |
| publishDate | 2019-08-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-025fa129574f4e269e1a85ff4f209f042023-09-15T10:32:01ZengTaylor & Francis GroupPlatelets0953-71041369-16352019-08-0130670871310.1080/09537104.2019.16101661610166Platelet glycoprotein VI genetic quantitative and qualitative defectsMartine Jandrot-Perrus0Cedric Hermans1Diego Mezzano2INSERM, University Paris DiderotSt-Luc University HospitalSchool of Medicine, Pontificia Universidad Católica de ChilePlatelet membrane glycoprotein VI (GPVI) is increasingly recognized as an important receptor for thrombus formation and growth. Numerous arguments have been published indicating that GPVI plays a major role in thrombosis without being essential for physiological hemostasis. In humans, GPVI deficiencies are rarely reported. These are most often deficiencies occurring in the context of autoimmunity and, more rarely, genetic deficits. The purpose of this review is to compile data on the quantitative and qualitative genetic abnormalities of GPVI.http://dx.doi.org/10.1080/09537104.2019.1610166glycoprotein vigenetic deficiencyplatelet disorder |
| spellingShingle | Martine Jandrot-Perrus Cedric Hermans Diego Mezzano Platelet glycoprotein VI genetic quantitative and qualitative defects Platelets glycoprotein vi genetic deficiency platelet disorder |
| title | Platelet glycoprotein VI genetic quantitative and qualitative defects |
| title_full | Platelet glycoprotein VI genetic quantitative and qualitative defects |
| title_fullStr | Platelet glycoprotein VI genetic quantitative and qualitative defects |
| title_full_unstemmed | Platelet glycoprotein VI genetic quantitative and qualitative defects |
| title_short | Platelet glycoprotein VI genetic quantitative and qualitative defects |
| title_sort | platelet glycoprotein vi genetic quantitative and qualitative defects |
| topic | glycoprotein vi genetic deficiency platelet disorder |
| url | http://dx.doi.org/10.1080/09537104.2019.1610166 |
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