Neuroinflammation Markers in Depressive Female Adolescents with Suicidal Attempts
Introduction Suicide is the second leading cause of death (8.5% of all deaths) in adolescents. The search for neurobiological markers of suicidal behavior seems to be highly actual. Such markers may include quantitative EEG parameters and signs of neuroinflammation that plays an important role in t...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-06-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933822006484/type/journal_article |
| _version_ | 1797617533105209344 |
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| author | A. Iznak E. Iznak E. Damyanovich I. Oleichik S. Zozulya |
| author_facet | A. Iznak E. Iznak E. Damyanovich I. Oleichik S. Zozulya |
| author_sort | A. Iznak |
| collection | DOAJ |
| description |
Introduction
Suicide is the second leading cause of death (8.5% of all deaths) in adolescents. The search for neurobiological markers of suicidal behavior seems to be highly actual. Such markers may include quantitative EEG parameters and signs of neuroinflammation that plays an important role in the pathogenesis of various mental disorders.
Objectives
The aim of the study was to reveal the relationships between pre-treatment clinical, EEG, and neuroimmunological parameters in depressive adolescents with suicidal attempts in their history.
Methods
35 female depressive patients (all right-handed, age 16–25, mean 18,7±2.9 years old) were enrolled in the study. Total HDRS-17 scores varied from 13 to 43 (mean 27,7±8.1). Multichannel resting EEG was recorded with spectral power (SP) measurements in narrow frequency sub-bands. Functional activities of leukocyte elastase (LE) and of its antagonist α1-proteinase inhibitor (α1-PI), as neuroinflammation markers, were measured in the blood plasma. Leukocyte/inhibitory index (LII=LE/α1-PI) was calculated. Spearman’s correlations between clinical, EEG, and neuroimmunological parameters were analyzed.
Results
Sum of anxiety cluster of HDRS-17 scale (items 9, 10, 11) correlated positively (p<0.02) with LE and α1-PI values, as well as with theta1 (4-6 Hz) and theta2 (6-8 Hz) SP in EEG leads of the right hemisphere. In turn, α1-PI values correlated negatively and LII values correlated positively with alpha3 (11-13 Hz) SP in majority of EEG leads.
Conclusions
The data obtained confirm the contribution of neuroinflammation to clinical conditions, especially to anxiety level, and to EEG pattern in depressive female adolescents with suicidal attempts. The study supported by RBRF grant No.20-013-00129a.
Disclosure
No significant relationships.
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| first_indexed | 2024-03-11T07:57:21Z |
| format | Article |
| id | doaj.art-0262a3f73e394a2f9f987080bb3e085a |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:57:21Z |
| publishDate | 2022-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-0262a3f73e394a2f9f987080bb3e085a2023-11-17T05:05:26ZengCambridge University PressEuropean Psychiatry0924-93381778-35852022-06-0165S251S25210.1192/j.eurpsy.2022.648Neuroinflammation Markers in Depressive Female Adolescents with Suicidal AttemptsA. Iznak0E. Iznak1E. Damyanovich2I. Oleichik3S. Zozulya4Mental Health Research Centre, Laboratory Of Neurophysiology, Moscow, Russian FederationMental Health Research Centre, Laboratory Of Neurophysiology, Moscow, Russian FederationMental Health Research Centre, Laboratory Of Neurophysiology, Moscow, Russian FederationMental Health Research Centre, Department Of Endogenous Mental Disorders And Affective Conditions, Moscow, Russian FederationMental Health Research Centre, Laboratory Of Neuroimmunology, Moscow, Russian Federation Introduction Suicide is the second leading cause of death (8.5% of all deaths) in adolescents. The search for neurobiological markers of suicidal behavior seems to be highly actual. Such markers may include quantitative EEG parameters and signs of neuroinflammation that plays an important role in the pathogenesis of various mental disorders. Objectives The aim of the study was to reveal the relationships between pre-treatment clinical, EEG, and neuroimmunological parameters in depressive adolescents with suicidal attempts in their history. Methods 35 female depressive patients (all right-handed, age 16–25, mean 18,7±2.9 years old) were enrolled in the study. Total HDRS-17 scores varied from 13 to 43 (mean 27,7±8.1). Multichannel resting EEG was recorded with spectral power (SP) measurements in narrow frequency sub-bands. Functional activities of leukocyte elastase (LE) and of its antagonist α1-proteinase inhibitor (α1-PI), as neuroinflammation markers, were measured in the blood plasma. Leukocyte/inhibitory index (LII=LE/α1-PI) was calculated. Spearman’s correlations between clinical, EEG, and neuroimmunological parameters were analyzed. Results Sum of anxiety cluster of HDRS-17 scale (items 9, 10, 11) correlated positively (p<0.02) with LE and α1-PI values, as well as with theta1 (4-6 Hz) and theta2 (6-8 Hz) SP in EEG leads of the right hemisphere. In turn, α1-PI values correlated negatively and LII values correlated positively with alpha3 (11-13 Hz) SP in majority of EEG leads. Conclusions The data obtained confirm the contribution of neuroinflammation to clinical conditions, especially to anxiety level, and to EEG pattern in depressive female adolescents with suicidal attempts. The study supported by RBRF grant No.20-013-00129a. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933822006484/type/journal_articlesuicidal attemptsneuroinflammationAdolescentsquantitative EEG |
| spellingShingle | A. Iznak E. Iznak E. Damyanovich I. Oleichik S. Zozulya Neuroinflammation Markers in Depressive Female Adolescents with Suicidal Attempts European Psychiatry suicidal attempts neuroinflammation Adolescents quantitative EEG |
| title | Neuroinflammation Markers in Depressive Female Adolescents with Suicidal Attempts |
| title_full | Neuroinflammation Markers in Depressive Female Adolescents with Suicidal Attempts |
| title_fullStr | Neuroinflammation Markers in Depressive Female Adolescents with Suicidal Attempts |
| title_full_unstemmed | Neuroinflammation Markers in Depressive Female Adolescents with Suicidal Attempts |
| title_short | Neuroinflammation Markers in Depressive Female Adolescents with Suicidal Attempts |
| title_sort | neuroinflammation markers in depressive female adolescents with suicidal attempts |
| topic | suicidal attempts neuroinflammation Adolescents quantitative EEG |
| url | https://www.cambridge.org/core/product/identifier/S0924933822006484/type/journal_article |
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