Tumor-Associated Macrophages and Related Myelomonocytic Cells in the Tumor Microenvironment of Multiple Myeloma
Multiple myeloma (MM) is the second-most common hematologic malignancy and remains incurable despite potent plasma cell directed therapeutics. The tumor microenvironment (TME) is a key player in the pathogenesis and progression of MM and is an active focus of research with a view to targeting immune...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/22/5654 |
| _version_ | 1797465684105494528 |
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| author | Samuel S. Y. Wang Wee Joo Chng Haiyan Liu Sanjay de Mel |
| author_facet | Samuel S. Y. Wang Wee Joo Chng Haiyan Liu Sanjay de Mel |
| author_sort | Samuel S. Y. Wang |
| collection | DOAJ |
| description | Multiple myeloma (MM) is the second-most common hematologic malignancy and remains incurable despite potent plasma cell directed therapeutics. The tumor microenvironment (TME) is a key player in the pathogenesis and progression of MM and is an active focus of research with a view to targeting immune dysregulation. Tumor-associated macrophages (TAM), myeloid derived suppressor cells (MDSC), and dendritic cells (DC) are known to drive progression and treatment resistance in many cancers. They have also been shown to promote MM progression and immune suppression in vitro, and there is growing evidence of their impact on clinical outcomes. The heterogeneity and functional characteristics of myelomonocytic cells in MM are being unraveled through high-dimensional immune profiling techniques. We are also beginning to understand how they may affect and be modulated by current and future MM therapeutics. In this review, we provide an overview of the biology and clinical relevance of TAMs, MDSCs, and DCs in the MM TME. We also highlight key areas to be addressed in future research as well as our perspectives on how the myelomonocytic compartment of the TME may influence therapeutic strategies of the future. |
| first_indexed | 2024-03-09T18:26:00Z |
| format | Article |
| id | doaj.art-02659ac77d9e46f4ba40ae61fcbd6173 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T18:26:00Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-02659ac77d9e46f4ba40ae61fcbd61732023-11-24T07:54:34ZengMDPI AGCancers2072-66942022-11-011422565410.3390/cancers14225654Tumor-Associated Macrophages and Related Myelomonocytic Cells in the Tumor Microenvironment of Multiple MyelomaSamuel S. Y. Wang0Wee Joo Chng1Haiyan Liu2Sanjay de Mel3Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore 308433, SingaporeDepartment of Haematology-Oncology, National University Cancer Institute Singapore, National University Health System, Singapore 119228, SingaporeImmunology Programme, Life Sciences Institute, National University of Singapore, Singapore 117456, SingaporeDepartment of Haematology-Oncology, National University Cancer Institute Singapore, National University Health System, Singapore 119228, SingaporeMultiple myeloma (MM) is the second-most common hematologic malignancy and remains incurable despite potent plasma cell directed therapeutics. The tumor microenvironment (TME) is a key player in the pathogenesis and progression of MM and is an active focus of research with a view to targeting immune dysregulation. Tumor-associated macrophages (TAM), myeloid derived suppressor cells (MDSC), and dendritic cells (DC) are known to drive progression and treatment resistance in many cancers. They have also been shown to promote MM progression and immune suppression in vitro, and there is growing evidence of their impact on clinical outcomes. The heterogeneity and functional characteristics of myelomonocytic cells in MM are being unraveled through high-dimensional immune profiling techniques. We are also beginning to understand how they may affect and be modulated by current and future MM therapeutics. In this review, we provide an overview of the biology and clinical relevance of TAMs, MDSCs, and DCs in the MM TME. We also highlight key areas to be addressed in future research as well as our perspectives on how the myelomonocytic compartment of the TME may influence therapeutic strategies of the future.https://www.mdpi.com/2072-6694/14/22/5654multiple myelomatumor-associated macrophagesmyeloid derived suppressor cellsdendritic cellstumor microenvironment |
| spellingShingle | Samuel S. Y. Wang Wee Joo Chng Haiyan Liu Sanjay de Mel Tumor-Associated Macrophages and Related Myelomonocytic Cells in the Tumor Microenvironment of Multiple Myeloma Cancers multiple myeloma tumor-associated macrophages myeloid derived suppressor cells dendritic cells tumor microenvironment |
| title | Tumor-Associated Macrophages and Related Myelomonocytic Cells in the Tumor Microenvironment of Multiple Myeloma |
| title_full | Tumor-Associated Macrophages and Related Myelomonocytic Cells in the Tumor Microenvironment of Multiple Myeloma |
| title_fullStr | Tumor-Associated Macrophages and Related Myelomonocytic Cells in the Tumor Microenvironment of Multiple Myeloma |
| title_full_unstemmed | Tumor-Associated Macrophages and Related Myelomonocytic Cells in the Tumor Microenvironment of Multiple Myeloma |
| title_short | Tumor-Associated Macrophages and Related Myelomonocytic Cells in the Tumor Microenvironment of Multiple Myeloma |
| title_sort | tumor associated macrophages and related myelomonocytic cells in the tumor microenvironment of multiple myeloma |
| topic | multiple myeloma tumor-associated macrophages myeloid derived suppressor cells dendritic cells tumor microenvironment |
| url | https://www.mdpi.com/2072-6694/14/22/5654 |
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