Integrative analysis of the lncRNA-miRNA-mRNA interactions in smooth muscle cell phenotypic transitions

Integrative analysis of the lncRNA-miRNA-mRNA interactions in smooth muscle cell phenotypic transitions

Objectives: We previously found that the pluripotency factor OCT4 is reactivated in smooth muscle cells (SMC) in human and mouse atherosclerotic plaques and plays an atheroprotective role. Loss of OCT4 in SMC in vitro was associated with decreases in SMC migration. However, molecular mechanisms resp...

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Bibliographic Details
Main Authors: Aatish Mahajan, Junyoung Hong, Irene Krukovets, Junchul Shin, Svyatoslav Tkachenko, Cristina Espinosa-Diez, Gary K. Owens, Olga A. Cherepanova
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Genetics
Subjects:
smooth muscle cells
long non-coding RNAs
micro RNAs
integrative analysis
OCT4 activation
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2024.1356558/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2024.1356558/full

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