Paraoxonases at the Heart of Neurological Disorders
Paraoxonase enzymes serve as an important physiological redox system that participates in the protection against cellular injury caused by oxidative stress. The PON enzymes family consists of three members (PON-1, PON-2, and PON-3) that share a similar structure and location as a cluster on human ch...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/8/6881 |
| _version_ | 1797605195054579712 |
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| author | Fatimah K. Khalaf Jacob Connolly Bella Khatib-Shahidi Abdulsahib Albehadili Iman Tassavvor Meghana Ranabothu Noha Eid Prabhatchandra Dube Samer J. Khouri Deepak Malhotra Steven T. Haller David J. Kennedy |
| author_facet | Fatimah K. Khalaf Jacob Connolly Bella Khatib-Shahidi Abdulsahib Albehadili Iman Tassavvor Meghana Ranabothu Noha Eid Prabhatchandra Dube Samer J. Khouri Deepak Malhotra Steven T. Haller David J. Kennedy |
| author_sort | Fatimah K. Khalaf |
| collection | DOAJ |
| description | Paraoxonase enzymes serve as an important physiological redox system that participates in the protection against cellular injury caused by oxidative stress. The PON enzymes family consists of three members (PON-1, PON-2, and PON-3) that share a similar structure and location as a cluster on human chromosome 7. These enzymes exhibit anti-inflammatory and antioxidant properties with well-described roles in preventing cardiovascular disease. Perturbations in PON enzyme levels and their activity have also been linked with the development and progression of many neurological disorders and neurodegenerative diseases. The current review summarizes the available evidence on the role of PONs in these diseases and their ability to modify risk factors for neurological disorders. We present the current findings on the role of PONs in Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative and neurological diseases. |
| first_indexed | 2024-03-11T04:57:40Z |
| format | Article |
| id | doaj.art-0267e5edcbf24f579e3407e0647d8ce1 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T04:57:40Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0267e5edcbf24f579e3407e0647d8ce12023-11-17T19:31:49ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01248688110.3390/ijms24086881Paraoxonases at the Heart of Neurological DisordersFatimah K. Khalaf0Jacob Connolly1Bella Khatib-Shahidi2Abdulsahib Albehadili3Iman Tassavvor4Meghana Ranabothu5Noha Eid6Prabhatchandra Dube7Samer J. Khouri8Deepak Malhotra9Steven T. Haller10David J. Kennedy11Department of Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43606, USADepartment of Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43606, USADepartment of Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43606, USADepartment of Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43606, USADepartment of Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43606, USADepartment of Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43606, USADepartment of Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43606, USADepartment of Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43606, USADepartment of Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43606, USADepartment of Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43606, USADepartment of Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43606, USADepartment of Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43606, USAParaoxonase enzymes serve as an important physiological redox system that participates in the protection against cellular injury caused by oxidative stress. The PON enzymes family consists of three members (PON-1, PON-2, and PON-3) that share a similar structure and location as a cluster on human chromosome 7. These enzymes exhibit anti-inflammatory and antioxidant properties with well-described roles in preventing cardiovascular disease. Perturbations in PON enzyme levels and their activity have also been linked with the development and progression of many neurological disorders and neurodegenerative diseases. The current review summarizes the available evidence on the role of PONs in these diseases and their ability to modify risk factors for neurological disorders. We present the current findings on the role of PONs in Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative and neurological diseases.https://www.mdpi.com/1422-0067/24/8/6881paraoxonasesneurodegenerative diseasesParkinson’s diseaseAlzheimer’s disease |
| spellingShingle | Fatimah K. Khalaf Jacob Connolly Bella Khatib-Shahidi Abdulsahib Albehadili Iman Tassavvor Meghana Ranabothu Noha Eid Prabhatchandra Dube Samer J. Khouri Deepak Malhotra Steven T. Haller David J. Kennedy Paraoxonases at the Heart of Neurological Disorders International Journal of Molecular Sciences paraoxonases neurodegenerative diseases Parkinson’s disease Alzheimer’s disease |
| title | Paraoxonases at the Heart of Neurological Disorders |
| title_full | Paraoxonases at the Heart of Neurological Disorders |
| title_fullStr | Paraoxonases at the Heart of Neurological Disorders |
| title_full_unstemmed | Paraoxonases at the Heart of Neurological Disorders |
| title_short | Paraoxonases at the Heart of Neurological Disorders |
| title_sort | paraoxonases at the heart of neurological disorders |
| topic | paraoxonases neurodegenerative diseases Parkinson’s disease Alzheimer’s disease |
| url | https://www.mdpi.com/1422-0067/24/8/6881 |
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