The Length of N-Glycans of Recombinant H5N1 Hemagglutinin Influences the Oligomerization and Immunogenicity of Vaccine Antigen

The Length of N-Glycans of Recombinant H5N1 Hemagglutinin Influences the Oligomerization and Immunogenicity of Vaccine Antigen

Hemagglutinin glycoprotein (HA) is a principle influenza vaccine antigen. Recombinant HA-based vaccines become a potential alternative for traditional approach. Complexity and variation of HA N-glycosylation are considered as the important factors for the vaccine design. The number and location of g...

Full description

Bibliographic Details
Main Authors: Edyta Kopera, Agnieszka Katarzyna Macioła, Maria Anna Pietrzak, Piotr Kosson, Mariusz Czarnocki-Cieciura, Krzysztof Śmietanka, Zenon Minta
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Immunology
Subjects:
avian influenza
H5N1
N-glycosylation
high-mannose glycosylation
low-mannose glycosylation
recombinant hemagglutinin
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00444/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00444/full

Similar Items