Anti-TNF-α Compounds as a Treatment for Depression
Millions of people around the world suffer from psychiatric illnesses, causing unbearable burden and immense distress to patients and their families. Accumulating evidence suggests that inflammation may contribute to the pathophysiology of psychiatric disorders such as major depression and bipolar d...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/26/8/2368 |
| _version_ | 1797537161387442176 |
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| author | Sarit Uzzan Abed N. Azab |
| author_facet | Sarit Uzzan Abed N. Azab |
| author_sort | Sarit Uzzan |
| collection | DOAJ |
| description | Millions of people around the world suffer from psychiatric illnesses, causing unbearable burden and immense distress to patients and their families. Accumulating evidence suggests that inflammation may contribute to the pathophysiology of psychiatric disorders such as major depression and bipolar disorder. Copious studies have consistently shown that patients with mood disorders have increased levels of plasma tumor necrosis factor (TNF)-α. Given these findings, selective anti-TNF-α compounds were tested as a potential therapeutic strategy for mood disorders. This mini-review summarizes the results of studies that examined the mood-modulating effects of anti-TNF-α drugs. |
| first_indexed | 2024-03-10T12:11:09Z |
| format | Article |
| id | doaj.art-026c1b900f7a4491be1052f137085801 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T12:11:09Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-026c1b900f7a4491be1052f1370858012023-11-21T16:10:53ZengMDPI AGMolecules1420-30492021-04-01268236810.3390/molecules26082368Anti-TNF-α Compounds as a Treatment for DepressionSarit Uzzan0Abed N. Azab1Department of Clinical Biochemistry and Pharmacology, School for Community Health Professions—Faculty of Health Sciences, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva 8410501, IsraelDepartment of Clinical Biochemistry and Pharmacology, School for Community Health Professions—Faculty of Health Sciences, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva 8410501, IsraelMillions of people around the world suffer from psychiatric illnesses, causing unbearable burden and immense distress to patients and their families. Accumulating evidence suggests that inflammation may contribute to the pathophysiology of psychiatric disorders such as major depression and bipolar disorder. Copious studies have consistently shown that patients with mood disorders have increased levels of plasma tumor necrosis factor (TNF)-α. Given these findings, selective anti-TNF-α compounds were tested as a potential therapeutic strategy for mood disorders. This mini-review summarizes the results of studies that examined the mood-modulating effects of anti-TNF-α drugs.https://www.mdpi.com/1420-3049/26/8/2368bipolar disorderdepressioninflammationpentoxifyllineTNF-αTNFR |
| spellingShingle | Sarit Uzzan Abed N. Azab Anti-TNF-α Compounds as a Treatment for Depression Molecules bipolar disorder depression inflammation pentoxifylline TNF-α TNFR |
| title | Anti-TNF-α Compounds as a Treatment for Depression |
| title_full | Anti-TNF-α Compounds as a Treatment for Depression |
| title_fullStr | Anti-TNF-α Compounds as a Treatment for Depression |
| title_full_unstemmed | Anti-TNF-α Compounds as a Treatment for Depression |
| title_short | Anti-TNF-α Compounds as a Treatment for Depression |
| title_sort | anti tnf α compounds as a treatment for depression |
| topic | bipolar disorder depression inflammation pentoxifylline TNF-α TNFR |
| url | https://www.mdpi.com/1420-3049/26/8/2368 |
| work_keys_str_mv | AT sarituzzan antitnfacompoundsasatreatmentfordepression AT abednazab antitnfacompoundsasatreatmentfordepression |