Rapid Antiretroviral Therapy Initiation for Women in an HIV-1 Prevention Clinical Trial Experiencing Primary HIV-1 Infection during Pregnancy or Breastfeeding.
During an HIV-1 prevention clinical trial in East Africa, we observed 16 cases of primary HIV-1 infection in women coincident with pregnancy or breastfeeding. Nine of eleven pregnant women initiated rapid combination antiretroviral therapy (ART), despite having CD4 counts exceeding national criteria...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4607156?pdf=render |
| _version_ | 1819198848797507584 |
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| author | Susan Morrison Grace John-Stewart John J Egessa Sezi Mubezi Sylvia Kusemererwa Dennis K Bii Nulu Bulya Francis Mugume James D Campbell Jonathan Wangisi Elizabeth A Bukusi Connie Celum Jared M Baeten Partners PrEP Study Team |
| author_facet | Susan Morrison Grace John-Stewart John J Egessa Sezi Mubezi Sylvia Kusemererwa Dennis K Bii Nulu Bulya Francis Mugume James D Campbell Jonathan Wangisi Elizabeth A Bukusi Connie Celum Jared M Baeten Partners PrEP Study Team |
| author_sort | Susan Morrison |
| collection | DOAJ |
| description | During an HIV-1 prevention clinical trial in East Africa, we observed 16 cases of primary HIV-1 infection in women coincident with pregnancy or breastfeeding. Nine of eleven pregnant women initiated rapid combination antiretroviral therapy (ART), despite having CD4 counts exceeding national criteria for ART initiation; breastfeeding women initiated ART or replacement feeding. Rapid ART initiation during primary HIV-1 infection during pregnancy and breastfeeding is feasible in this setting. |
| first_indexed | 2024-12-23T03:06:58Z |
| format | Article |
| id | doaj.art-026c627b44724751979eda2b3012d3ec |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T03:06:58Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-026c627b44724751979eda2b3012d3ec2022-12-21T18:02:18ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011010e014077310.1371/journal.pone.0140773Rapid Antiretroviral Therapy Initiation for Women in an HIV-1 Prevention Clinical Trial Experiencing Primary HIV-1 Infection during Pregnancy or Breastfeeding.Susan MorrisonGrace John-StewartJohn J EgessaSezi MubeziSylvia KusemererwaDennis K BiiNulu BulyaFrancis MugumeJames D CampbellJonathan WangisiElizabeth A BukusiConnie CelumJared M BaetenPartners PrEP Study TeamDuring an HIV-1 prevention clinical trial in East Africa, we observed 16 cases of primary HIV-1 infection in women coincident with pregnancy or breastfeeding. Nine of eleven pregnant women initiated rapid combination antiretroviral therapy (ART), despite having CD4 counts exceeding national criteria for ART initiation; breastfeeding women initiated ART or replacement feeding. Rapid ART initiation during primary HIV-1 infection during pregnancy and breastfeeding is feasible in this setting.http://europepmc.org/articles/PMC4607156?pdf=render |
| spellingShingle | Susan Morrison Grace John-Stewart John J Egessa Sezi Mubezi Sylvia Kusemererwa Dennis K Bii Nulu Bulya Francis Mugume James D Campbell Jonathan Wangisi Elizabeth A Bukusi Connie Celum Jared M Baeten Partners PrEP Study Team Rapid Antiretroviral Therapy Initiation for Women in an HIV-1 Prevention Clinical Trial Experiencing Primary HIV-1 Infection during Pregnancy or Breastfeeding. PLoS ONE |
| title | Rapid Antiretroviral Therapy Initiation for Women in an HIV-1 Prevention Clinical Trial Experiencing Primary HIV-1 Infection during Pregnancy or Breastfeeding. |
| title_full | Rapid Antiretroviral Therapy Initiation for Women in an HIV-1 Prevention Clinical Trial Experiencing Primary HIV-1 Infection during Pregnancy or Breastfeeding. |
| title_fullStr | Rapid Antiretroviral Therapy Initiation for Women in an HIV-1 Prevention Clinical Trial Experiencing Primary HIV-1 Infection during Pregnancy or Breastfeeding. |
| title_full_unstemmed | Rapid Antiretroviral Therapy Initiation for Women in an HIV-1 Prevention Clinical Trial Experiencing Primary HIV-1 Infection during Pregnancy or Breastfeeding. |
| title_short | Rapid Antiretroviral Therapy Initiation for Women in an HIV-1 Prevention Clinical Trial Experiencing Primary HIV-1 Infection during Pregnancy or Breastfeeding. |
| title_sort | rapid antiretroviral therapy initiation for women in an hiv 1 prevention clinical trial experiencing primary hiv 1 infection during pregnancy or breastfeeding |
| url | http://europepmc.org/articles/PMC4607156?pdf=render |
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