MRI Measures of Hippocampus in Mild Cognitive Impairment and Alzheimer Patients
OBJECTIVE: In this study we aimed to compare the hippocampal volumes of patients diagnosed as Alzheimer’s Disease (AD), Minimal Cognitive Impairment (MCI) and the healthy objects. We also tried to demonstrate whether there was a possible correlation between the cognitive tests and the hippocampal vo...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2011-12-01
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| Series: | Türk Nöroloji Dergisi |
| Subjects: | |
| Online Access: | http://www.tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-35582 |
| _version_ | 1828021443398467584 |
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| author | Çağatay Öncel Bülent Özdemir Çağdaş Erdoğan Yılmaz Kıroğlu Türker Şahiner |
| author_facet | Çağatay Öncel Bülent Özdemir Çağdaş Erdoğan Yılmaz Kıroğlu Türker Şahiner |
| author_sort | Çağatay Öncel |
| collection | DOAJ |
| description | OBJECTIVE: In this study we aimed to compare the hippocampal volumes of patients diagnosed as Alzheimer’s Disease (AD), Minimal Cognitive Impairment (MCI) and the healthy objects. We also tried to demonstrate whether there was a possible correlation between the cognitive tests and the hippocampal volumes.
METHODS: Minimental State Examination, Adas-Cog and Global Deterioration Scale were administrated to the patients having Alzheimer’s Disease (n=20). We also performed Minimental State Examination, and Adas-Cog to MCI patients (n=20) and Minimental State Examination to the healthy control group (n=18).
Both right and left hippocampal volumes were measured by a three dimensioned Surf Driver programm with the support of cranial magnetic resonance imaging (MRI).
RESULTS: Both right and left hippocampal volumes of the Alzheimer’s Disease group were significantly smaller than the MCI and the control groups. Bilaterally hippocampal volumes of MCI group were also smaller than the control group. (Hippocampal volumes; AD < MCI < control groups). The differences between the right and the left hippocampal volumes were not significant in both AD and MCI groups. There were no significant correlations between the cognitive tests and the hippocampal volumes(p>0.05).
CONCLUSION: : Surf Driver method succesfully demonstrated the relative hippocampal atrophy in the AD and the MCI groups when compared with the healthy controls |
| first_indexed | 2024-04-10T11:53:18Z |
| format | Article |
| id | doaj.art-026cc8dfb2b345bc8029c7cd37bacbf8 |
| institution | Directory Open Access Journal |
| issn | 1301-062X 1309-2545 |
| language | English |
| last_indexed | 2024-04-10T11:53:18Z |
| publishDate | 2011-12-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Nöroloji Dergisi |
| spelling | doaj.art-026cc8dfb2b345bc8029c7cd37bacbf82023-02-15T16:17:01ZengGalenos YayineviTürk Nöroloji Dergisi1301-062X1309-25452011-12-01174181184MRI Measures of Hippocampus in Mild Cognitive Impairment and Alzheimer PatientsÇağatay Öncel0Bülent Özdemir1Çağdaş Erdoğan2Yılmaz Kıroğlu3Türker Şahiner4Department Of Neurology, Pamukkale University, Denizli, TurkeyDepartment Of Anatomy, Pamukkale University, Denizli, TurkeyDepartment Of Neurology, Pamukkale University, Denizli, TurkeyDepartment Of Radiology, Pamukkale University, Denizli, TurkeyAnadolu Medical Center, İstanbul, TurkeyOBJECTIVE: In this study we aimed to compare the hippocampal volumes of patients diagnosed as Alzheimer’s Disease (AD), Minimal Cognitive Impairment (MCI) and the healthy objects. We also tried to demonstrate whether there was a possible correlation between the cognitive tests and the hippocampal volumes. METHODS: Minimental State Examination, Adas-Cog and Global Deterioration Scale were administrated to the patients having Alzheimer’s Disease (n=20). We also performed Minimental State Examination, and Adas-Cog to MCI patients (n=20) and Minimental State Examination to the healthy control group (n=18). Both right and left hippocampal volumes were measured by a three dimensioned Surf Driver programm with the support of cranial magnetic resonance imaging (MRI). RESULTS: Both right and left hippocampal volumes of the Alzheimer’s Disease group were significantly smaller than the MCI and the control groups. Bilaterally hippocampal volumes of MCI group were also smaller than the control group. (Hippocampal volumes; AD < MCI < control groups). The differences between the right and the left hippocampal volumes were not significant in both AD and MCI groups. There were no significant correlations between the cognitive tests and the hippocampal volumes(p>0.05). CONCLUSION: : Surf Driver method succesfully demonstrated the relative hippocampal atrophy in the AD and the MCI groups when compared with the healthy controlshttp://www.tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-35582HippocampusAlzheimer diseasemild cognitive impairmentmagnetic resonance imaging |
| spellingShingle | Çağatay Öncel Bülent Özdemir Çağdaş Erdoğan Yılmaz Kıroğlu Türker Şahiner MRI Measures of Hippocampus in Mild Cognitive Impairment and Alzheimer Patients Türk Nöroloji Dergisi Hippocampus Alzheimer disease mild cognitive impairment magnetic resonance imaging |
| title | MRI Measures of Hippocampus in Mild Cognitive Impairment and Alzheimer Patients |
| title_full | MRI Measures of Hippocampus in Mild Cognitive Impairment and Alzheimer Patients |
| title_fullStr | MRI Measures of Hippocampus in Mild Cognitive Impairment and Alzheimer Patients |
| title_full_unstemmed | MRI Measures of Hippocampus in Mild Cognitive Impairment and Alzheimer Patients |
| title_short | MRI Measures of Hippocampus in Mild Cognitive Impairment and Alzheimer Patients |
| title_sort | mri measures of hippocampus in mild cognitive impairment and alzheimer patients |
| topic | Hippocampus Alzheimer disease mild cognitive impairment magnetic resonance imaging |
| url | http://www.tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-35582 |
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