Suramin prevents the development of diabetic kidney disease by inhibiting NLRP3 inflammasome activation in KK‐Ay mice

Suramin prevents the development of diabetic kidney disease by inhibiting NLRP3 inflammasome activation in KK‐Ay mice

Abstract Aims/Introduction Nucleotide‐binding oligomerization domain‐like receptor family pyrin domain containing 3 (NLRP3) inflammasomes produce IL‐18 upon being activated by various stimuli via the P2 receptors. Previously, we showed that serum and urine IL‐18 levels are positively associated with...

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Bibliographic Details
Main Authors:	Kaori Oda, Satoshi Miyamoto, Ryo Kodera, Jun Wada, Kenichi Shikata
Format:	Article
Language:	English
Published:	Wiley 2023-02-01
Series:	Journal of Diabetes Investigation
Subjects:	Diabetic kidney disease Inflammasomes Suramin
Online Access:	https://doi.org/10.1111/jdi.13930

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