A modified lung ultrasound score to evaluate short-term clinical outcomes of bronchopulmonary dysplasia
Abstract Background Lung ultrasound (LUS) is a useful tool for assessing the severity of lung disease, without radiation exposure. However, there is little data on the practicality of LUS in assessing the severity of bronchopulmonary dysplasia (BPD) and evaluating short-term clinical outcomes. We ad...
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| Format: | Article |
| Language: | English |
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BMC
2022-03-01
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| Series: | BMC Pulmonary Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12890-022-01885-4 |
| _version_ | 1818773597768908800 |
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| author | Ying-Hua Sun Yang Du Jie-Ru Shen Dan-Yang Ai Xiang-Yuan Huang Si-Hao Diao Sam Bill Lin Rong Zhang Lin Yuan Yi-Pei Yang Li-Li He Xiao-Jiao Qin Jian-Guo Zhou Chao Chen |
| author_facet | Ying-Hua Sun Yang Du Jie-Ru Shen Dan-Yang Ai Xiang-Yuan Huang Si-Hao Diao Sam Bill Lin Rong Zhang Lin Yuan Yi-Pei Yang Li-Li He Xiao-Jiao Qin Jian-Guo Zhou Chao Chen |
| author_sort | Ying-Hua Sun |
| collection | DOAJ |
| description | Abstract Background Lung ultrasound (LUS) is a useful tool for assessing the severity of lung disease, without radiation exposure. However, there is little data on the practicality of LUS in assessing the severity of bronchopulmonary dysplasia (BPD) and evaluating short-term clinical outcomes. We adapted a LUS score to evaluate BPD severity and assess the reliability of mLUS score correlated with short-term clinical outcomes. Methods Prospective diagnostic accuracy study was designed to enroll preterm infants with gestational age < 34 weeks. Lung ultrasonography was performed at 36 weeks postmenstrual age. The diagnostic and predictive values of new modified lung ultrasound (mLUS) scores based on eight standard sections were compared with classic lung ultrasound (cLUS) scores. Results A total of 128 infants were enrolled in this cohort, including 30 without BPD; 31 with mild BPD; 23 with moderate BPD and 44 with severe BPD. The mLUS score was significantly correlated with the short-term clinical outcomes, superior to cLUS score. The mLUS score well correlated with moderate and severe BPD (AUC = 0.813, 95% CI 0.739–0.888) and severe BPD (AUC = 0.801, 95% CI 0.728–0.875), which were superior to cLUS score. The ROC analysis of mLUS score to evaluate the other short-term outcomes also showed significant superiority to cLUS score. The optimal cutoff points for mLUS score were 14 for moderate and severe BPD and 16 for severe BPD. Conclusions The mLUS score correlates significantly with short-term clinical outcomes and well evaluates these outcomes in preterm infants. |
| first_indexed | 2024-12-18T10:27:47Z |
| format | Article |
| id | doaj.art-026eb940036c43ff8aab697d2f36ac3d |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-12-18T10:27:47Z |
| publishDate | 2022-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-026eb940036c43ff8aab697d2f36ac3d2022-12-21T21:10:57ZengBMCBMC Pulmonary Medicine1471-24662022-03-0122111110.1186/s12890-022-01885-4A modified lung ultrasound score to evaluate short-term clinical outcomes of bronchopulmonary dysplasiaYing-Hua Sun0Yang Du1Jie-Ru Shen2Dan-Yang Ai3Xiang-Yuan Huang4Si-Hao Diao5Sam Bill Lin6Rong Zhang7Lin Yuan8Yi-Pei Yang9Li-Li He10Xiao-Jiao Qin11Jian-Guo Zhou12Chao Chen13Department of Neonatology, Children’s Hospital of Fudan University, National Children’s Medical CenterDepartment of Neonatology, Children’s Hospital of Fudan University, National Children’s Medical CenterDepartment of Neonatology, Children’s Hospital of Fudan University, National Children’s Medical CenterDepartment of Neonatology, Children’s Hospital of Fudan University, National Children’s Medical CenterDepartment of Clinical Epidemiology, Children’s Hospital of Fudan University, National Children’s Medical CenterDepartment of Neonatology, Children’s Hospital of Fudan University, National Children’s Medical CenterDepartment of Neonatology, Children’s Hospital of Fudan University, National Children’s Medical CenterDepartment of Neonatology, Children’s Hospital of Fudan University, National Children’s Medical CenterDepartment of Neonatology, Children’s Hospital of Fudan University, National Children’s Medical CenterDepartment of Neonatology, Children’s Hospital of Fudan University, National Children’s Medical CenterDepartment of Ultrasound, Children’s Hospital of Fudan University, National Children’s Medical CenterDepartment of Ultrasound, Children’s Hospital of Fudan University, National Children’s Medical CenterDepartment of Neonatology, Children’s Hospital of Fudan University, National Children’s Medical CenterDepartment of Neonatology, Children’s Hospital of Fudan University, National Children’s Medical CenterAbstract Background Lung ultrasound (LUS) is a useful tool for assessing the severity of lung disease, without radiation exposure. However, there is little data on the practicality of LUS in assessing the severity of bronchopulmonary dysplasia (BPD) and evaluating short-term clinical outcomes. We adapted a LUS score to evaluate BPD severity and assess the reliability of mLUS score correlated with short-term clinical outcomes. Methods Prospective diagnostic accuracy study was designed to enroll preterm infants with gestational age < 34 weeks. Lung ultrasonography was performed at 36 weeks postmenstrual age. The diagnostic and predictive values of new modified lung ultrasound (mLUS) scores based on eight standard sections were compared with classic lung ultrasound (cLUS) scores. Results A total of 128 infants were enrolled in this cohort, including 30 without BPD; 31 with mild BPD; 23 with moderate BPD and 44 with severe BPD. The mLUS score was significantly correlated with the short-term clinical outcomes, superior to cLUS score. The mLUS score well correlated with moderate and severe BPD (AUC = 0.813, 95% CI 0.739–0.888) and severe BPD (AUC = 0.801, 95% CI 0.728–0.875), which were superior to cLUS score. The ROC analysis of mLUS score to evaluate the other short-term outcomes also showed significant superiority to cLUS score. The optimal cutoff points for mLUS score were 14 for moderate and severe BPD and 16 for severe BPD. Conclusions The mLUS score correlates significantly with short-term clinical outcomes and well evaluates these outcomes in preterm infants.https://doi.org/10.1186/s12890-022-01885-4Lung ultrasoundBronchopulmonary dysplasiaPremature |
| spellingShingle | Ying-Hua Sun Yang Du Jie-Ru Shen Dan-Yang Ai Xiang-Yuan Huang Si-Hao Diao Sam Bill Lin Rong Zhang Lin Yuan Yi-Pei Yang Li-Li He Xiao-Jiao Qin Jian-Guo Zhou Chao Chen A modified lung ultrasound score to evaluate short-term clinical outcomes of bronchopulmonary dysplasia BMC Pulmonary Medicine Lung ultrasound Bronchopulmonary dysplasia Premature |
| title | A modified lung ultrasound score to evaluate short-term clinical outcomes of bronchopulmonary dysplasia |
| title_full | A modified lung ultrasound score to evaluate short-term clinical outcomes of bronchopulmonary dysplasia |
| title_fullStr | A modified lung ultrasound score to evaluate short-term clinical outcomes of bronchopulmonary dysplasia |
| title_full_unstemmed | A modified lung ultrasound score to evaluate short-term clinical outcomes of bronchopulmonary dysplasia |
| title_short | A modified lung ultrasound score to evaluate short-term clinical outcomes of bronchopulmonary dysplasia |
| title_sort | modified lung ultrasound score to evaluate short term clinical outcomes of bronchopulmonary dysplasia |
| topic | Lung ultrasound Bronchopulmonary dysplasia Premature |
| url | https://doi.org/10.1186/s12890-022-01885-4 |
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