Distinct role of mitochondrial function and protein kinase C in intimal and medial calcification in vitro

Distinct role of mitochondrial function and protein kinase C in intimal and medial calcification in vitro

IntroductionVascular calcification (VC) is a major risk factor for cardiovascular morbidity and mortality. Depending on the location of mineral deposition within the arterial wall, VC is classified as intimal and medial calcification. Using in vitro mineralization assays, we developed protocols trig...

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Bibliographic Details
Main Authors: Marina A. Heuschkel, Anne Babler, Jonas Heyn, Emiel P. C. van der Vorst, Marja Steenman, Maren Gesper, Ben A. Kappel, David Magne, Yann Gouëffic, Rafael Kramann, Willi Jahnen-Dechent, Nikolaus Marx, Thibaut Quillard, Claudia Goettsch
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
vascular calcification
vascular smooth muscle cells
drug repurposing
mitochondrial function
matrix mineralization
protein kinase C
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.959457/full

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