MET and Small-Cell Lung Cancer
Small-cell lung cancer (SCLC) is one of the most aggressive lung tumors. The majority of patients with SCLC are diagnosed at an advanced stage. This tumor type is highly sensitive to chemo-radiation treatment, with very high response rates, but invariably relapses. At this time, treatment options ar...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-10-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6694/6/4/2100 |
| _version_ | 1797723014873219072 |
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| author | Francesco Gelsomino Giulio Rossi Marcello Tiseo |
| author_facet | Francesco Gelsomino Giulio Rossi Marcello Tiseo |
| author_sort | Francesco Gelsomino |
| collection | DOAJ |
| description | Small-cell lung cancer (SCLC) is one of the most aggressive lung tumors. The majority of patients with SCLC are diagnosed at an advanced stage. This tumor type is highly sensitive to chemo-radiation treatment, with very high response rates, but invariably relapses. At this time, treatment options are still limited and the prognosis of these patients is poor. A better knowledge of the molecular biology of SCLC allowed us to identify potential druggable targets. Among these, the MET/HGF axis seems to be one of the most aberrant signaling pathways involved in SCLC invasiveness and progression. In this review, we describe briefly all recent literature on the different molecular profiling in SCLC; in particular, we discuss the specific alterations involving c-MET gene and their implications as a potential target in SCLC. |
| first_indexed | 2024-03-12T09:56:03Z |
| format | Article |
| id | doaj.art-026fb3bc3b7c44c3a4e6662af68da681 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T09:56:03Z |
| publishDate | 2014-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-026fb3bc3b7c44c3a4e6662af68da6812023-09-02T12:08:21ZengMDPI AGCancers2072-66942014-10-01642100211510.3390/cancers6042100cancers6042100MET and Small-Cell Lung CancerFrancesco Gelsomino0Giulio Rossi1Marcello Tiseo2Medical Oncology Unit 1, Medical Oncology Department, Fondazione IRCCS Istituto Nazionale Tumori, Via G. Venezian 1, 20133 Milano, ItalyOperative Unit of Pathology, Azienda Ospedaliero-Universitaria Policlinico, Via del Pozzo 71, 41124 Modena, ItalyMedical Oncology Unit, Azienda Ospedaliero-Universitaria, Viale A. Gramsci 14, 43126 Parma, ItalySmall-cell lung cancer (SCLC) is one of the most aggressive lung tumors. The majority of patients with SCLC are diagnosed at an advanced stage. This tumor type is highly sensitive to chemo-radiation treatment, with very high response rates, but invariably relapses. At this time, treatment options are still limited and the prognosis of these patients is poor. A better knowledge of the molecular biology of SCLC allowed us to identify potential druggable targets. Among these, the MET/HGF axis seems to be one of the most aberrant signaling pathways involved in SCLC invasiveness and progression. In this review, we describe briefly all recent literature on the different molecular profiling in SCLC; in particular, we discuss the specific alterations involving c-MET gene and their implications as a potential target in SCLC.http://www.mdpi.com/2072-6694/6/4/2100c-METsmall-cell lung cancermutationsc-MET signaling pathway |
| spellingShingle | Francesco Gelsomino Giulio Rossi Marcello Tiseo MET and Small-Cell Lung Cancer Cancers c-MET small-cell lung cancer mutations c-MET signaling pathway |
| title | MET and Small-Cell Lung Cancer |
| title_full | MET and Small-Cell Lung Cancer |
| title_fullStr | MET and Small-Cell Lung Cancer |
| title_full_unstemmed | MET and Small-Cell Lung Cancer |
| title_short | MET and Small-Cell Lung Cancer |
| title_sort | met and small cell lung cancer |
| topic | c-MET small-cell lung cancer mutations c-MET signaling pathway |
| url | http://www.mdpi.com/2072-6694/6/4/2100 |
| work_keys_str_mv | AT francescogelsomino metandsmallcelllungcancer AT giuliorossi metandsmallcelllungcancer AT marcellotiseo metandsmallcelllungcancer |