Targeted Doxorubicin-Loaded Dendronized Gold Nanoparticles
Dendronized nanoparticles, also called nanoparticle-cored dendrimers, combine the advantages of nanoparticles and dendrimers. These very stable and polyvalent nanoparticles can be used for diverse applications. One such application is drug delivery, because the dendrons can enhance the density of th...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/15/8/2103 |
| _version_ | 1797583457133527040 |
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| author | Lance T. Dockery Marie-Christine Daniel |
| author_facet | Lance T. Dockery Marie-Christine Daniel |
| author_sort | Lance T. Dockery |
| collection | DOAJ |
| description | Dendronized nanoparticles, also called nanoparticle-cored dendrimers, combine the advantages of nanoparticles and dendrimers. These very stable and polyvalent nanoparticles can be used for diverse applications. One such application is drug delivery, because the dendrons can enhance the density of the payload. In this report, we describe the design of multifunctional gold nanoparticles (AuNPs) coated with poly(propylene imine) (PPI) dendrons that contain both prostate cancer active targeting and chemotherapeutic drugs. The PPI dendron is a good candidate for the design of drug delivery vehicles because of its ability to induce a proton sponge effect that will enhance lysosomal escape and intracellular therapeutic delivery. The chemotherapeutic drug used is doxorubicin (DOX), and it was linked to the dendron through a hydrazone acid-sensitive bond. Subsequent acidification of the AuNP system to a pH of 4–5 resulted in the release of 140 DOX drugs per nanoparticles. In addition, the PPI dendron was conjugated via “click” chemistry to an EphA2-targeting antibody fragment that has been shown to target prostate cancer cells. In vitro cell viability assays revealed an IC50 of 0.9 nM for the targeted DOX-bearing AuNPs after 48 h incubation with PC3 cells. These results are very promising upon optimization of the system. |
| first_indexed | 2024-03-10T23:39:11Z |
| format | Article |
| id | doaj.art-0272de8c6cb249e6a842e5f3b692857e |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T23:39:11Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-0272de8c6cb249e6a842e5f3b692857e2023-11-19T02:36:51ZengMDPI AGPharmaceutics1999-49232023-08-01158210310.3390/pharmaceutics15082103Targeted Doxorubicin-Loaded Dendronized Gold NanoparticlesLance T. Dockery0Marie-Christine Daniel1Department of Chemistry and Biochemistry, University of Maryland Baltimore County (UMBC), Baltimore, MD 21250, USADepartment of Chemistry and Biochemistry, University of Maryland Baltimore County (UMBC), Baltimore, MD 21250, USADendronized nanoparticles, also called nanoparticle-cored dendrimers, combine the advantages of nanoparticles and dendrimers. These very stable and polyvalent nanoparticles can be used for diverse applications. One such application is drug delivery, because the dendrons can enhance the density of the payload. In this report, we describe the design of multifunctional gold nanoparticles (AuNPs) coated with poly(propylene imine) (PPI) dendrons that contain both prostate cancer active targeting and chemotherapeutic drugs. The PPI dendron is a good candidate for the design of drug delivery vehicles because of its ability to induce a proton sponge effect that will enhance lysosomal escape and intracellular therapeutic delivery. The chemotherapeutic drug used is doxorubicin (DOX), and it was linked to the dendron through a hydrazone acid-sensitive bond. Subsequent acidification of the AuNP system to a pH of 4–5 resulted in the release of 140 DOX drugs per nanoparticles. In addition, the PPI dendron was conjugated via “click” chemistry to an EphA2-targeting antibody fragment that has been shown to target prostate cancer cells. In vitro cell viability assays revealed an IC50 of 0.9 nM for the targeted DOX-bearing AuNPs after 48 h incubation with PC3 cells. These results are very promising upon optimization of the system.https://www.mdpi.com/1999-4923/15/8/2103dendronsgold nanoparticlesdoxorubicintargeted deliveryprostate cancer |
| spellingShingle | Lance T. Dockery Marie-Christine Daniel Targeted Doxorubicin-Loaded Dendronized Gold Nanoparticles Pharmaceutics dendrons gold nanoparticles doxorubicin targeted delivery prostate cancer |
| title | Targeted Doxorubicin-Loaded Dendronized Gold Nanoparticles |
| title_full | Targeted Doxorubicin-Loaded Dendronized Gold Nanoparticles |
| title_fullStr | Targeted Doxorubicin-Loaded Dendronized Gold Nanoparticles |
| title_full_unstemmed | Targeted Doxorubicin-Loaded Dendronized Gold Nanoparticles |
| title_short | Targeted Doxorubicin-Loaded Dendronized Gold Nanoparticles |
| title_sort | targeted doxorubicin loaded dendronized gold nanoparticles |
| topic | dendrons gold nanoparticles doxorubicin targeted delivery prostate cancer |
| url | https://www.mdpi.com/1999-4923/15/8/2103 |
| work_keys_str_mv | AT lancetdockery targeteddoxorubicinloadeddendronizedgoldnanoparticles AT mariechristinedaniel targeteddoxorubicinloadeddendronizedgoldnanoparticles |