Stereoselective Synthesis of Fluoroalkanes via FLP Mediated Monoselective C─F Activation of Geminal Difluoroalkanes

Stereoselective Synthesis of Fluoroalkanes via FLP Mediated Monoselective C─F Activation of Geminal Difluoroalkanes

Abstract A method of desymmetrization of geminal difluoroalkanes using frustrated Lewis pair (FLP) mediated monoselective C–F activation where a chiral sulfide is the Lewis base component is reported. The stereoselective reaction provides generally high yields of diastereomeric sulfonium salts with...

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Bibliographic Details
Main Authors: Dániel Csókás, Bivas Mondal, Miloš Đokić, Richa Gupta, Beatrice J. Y. Lee, Rowan D. Young
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:Advanced Science
Subjects:
asymmetric synthesis
carbon–fluorine activation
difluoromethyl desymmetrization
frustrated Lewis pair
stereoselective
Online Access:https://doi.org/10.1002/advs.202305768

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