The relationship between TGF-β1 and cognitive function in the brain
Transforming growth factor-β1 (TGF-β1), a multifunctional cytokine, plays a pivotal role in synaptic formation, plasticity, and neurovascular unit regulation. This review highlights TGF-β1's potential impact on cognitive function, particularly in the context of neurodegenerative disorders. Howe...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Brain Research Bulletin |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923023002459 |
| _version_ | 1797398671884550144 |
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| author | Chen Su Jie Miao Junhong Guo |
| author_facet | Chen Su Jie Miao Junhong Guo |
| author_sort | Chen Su |
| collection | DOAJ |
| description | Transforming growth factor-β1 (TGF-β1), a multifunctional cytokine, plays a pivotal role in synaptic formation, plasticity, and neurovascular unit regulation. This review highlights TGF-β1's potential impact on cognitive function, particularly in the context of neurodegenerative disorders. However, despite the growing body of evidence, a comprehensive understanding of TGF-β1's precise role remains elusive. Further research is essential to unravel the complex mechanisms through which TGF-β1 influences cognitive function and to explore therapeutic avenues for targeting TGF-β1 in neurodegenerative conditions. This investigation sheds light on TGF-β1's contribution to cognitive function and offers prospects for innovative treatments and interventions. This review delves into the intricate relationship between TGF-β1 and cognitive function. |
| first_indexed | 2024-03-09T01:28:57Z |
| format | Article |
| id | doaj.art-02745afcec4f41d59257b834306ec22b |
| institution | Directory Open Access Journal |
| issn | 1873-2747 |
| language | English |
| last_indexed | 2024-03-09T01:28:57Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj.art-02745afcec4f41d59257b834306ec22b2023-12-10T06:13:46ZengElsevierBrain Research Bulletin1873-27472023-12-01205110820The relationship between TGF-β1 and cognitive function in the brainChen Su0Jie Miao1Junhong Guo2Department of Neurology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi Province 030000, ChinaDepartment of Neurology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi Province 030000, ChinaCorresponding author.; Department of Neurology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi Province 030000, ChinaTransforming growth factor-β1 (TGF-β1), a multifunctional cytokine, plays a pivotal role in synaptic formation, plasticity, and neurovascular unit regulation. This review highlights TGF-β1's potential impact on cognitive function, particularly in the context of neurodegenerative disorders. However, despite the growing body of evidence, a comprehensive understanding of TGF-β1's precise role remains elusive. Further research is essential to unravel the complex mechanisms through which TGF-β1 influences cognitive function and to explore therapeutic avenues for targeting TGF-β1 in neurodegenerative conditions. This investigation sheds light on TGF-β1's contribution to cognitive function and offers prospects for innovative treatments and interventions. This review delves into the intricate relationship between TGF-β1 and cognitive function.http://www.sciencedirect.com/science/article/pii/S0361923023002459TGF-β1CognitionSynapsesNeurovascular unitNeurological diseases |
| spellingShingle | Chen Su Jie Miao Junhong Guo The relationship between TGF-β1 and cognitive function in the brain Brain Research Bulletin TGF-β1 Cognition Synapses Neurovascular unit Neurological diseases |
| title | The relationship between TGF-β1 and cognitive function in the brain |
| title_full | The relationship between TGF-β1 and cognitive function in the brain |
| title_fullStr | The relationship between TGF-β1 and cognitive function in the brain |
| title_full_unstemmed | The relationship between TGF-β1 and cognitive function in the brain |
| title_short | The relationship between TGF-β1 and cognitive function in the brain |
| title_sort | relationship between tgf β1 and cognitive function in the brain |
| topic | TGF-β1 Cognition Synapses Neurovascular unit Neurological diseases |
| url | http://www.sciencedirect.com/science/article/pii/S0361923023002459 |
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