A 12.3-kb Duplication Within the VWF Gene in Pigs Affected by Von Willebrand Disease Type 3

A 12.3-kb Duplication Within the VWF Gene in Pigs Affected by Von Willebrand Disease Type 3

Von Willebrand Disease (VWD) type 3 is a serious and sometimes fatal hereditary bleeding disorder. In pigs, the disease has been known for decades, and affected animals are used as models for the human disease. Due to the recessive mode of inheritance of VWD type 3, severe bleeding is typically seen...

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Bibliographic Details
Main Authors: Stefanie Lehner, Mahnaz Ekhlasi-Hundrieser, Carsten Detering, Hanna Allerkamp, Christiane Pfarrer, Mario von Depka Prondzinski
Format: Article
Language:English
Published: Oxford University Press 2018-02-01
Series:G3: Genes, Genomes, Genetics
Subjects:
Sus scrofa
Von Willebrand factor
Bleeding disorder
Frameshift
Nonsense-mediated decay
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.117.300432

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