Independent predictive value of blood inflammatory composite markers in ovarian cancer: recent clinical evidence and perspective focusing on NLR and PLR
Abstract Ovarian cancer (OC) is one of the deadliest malignant tumors affecting women worldwide. The predictive value of some blood inflammatory composite markers in OC has been extensively reported. They can be used for early detection and differential diagnosis of OC and can be used for predicting...
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | Journal of Ovarian Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13048-023-01116-2 |
| _version_ | 1828035077796265984 |
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| author | Chuan-long Zhang Xiao-chen Jiang Yi Li Xue Pan Meng-qi Gao Yan Chen Bo Pang |
| author_facet | Chuan-long Zhang Xiao-chen Jiang Yi Li Xue Pan Meng-qi Gao Yan Chen Bo Pang |
| author_sort | Chuan-long Zhang |
| collection | DOAJ |
| description | Abstract Ovarian cancer (OC) is one of the deadliest malignant tumors affecting women worldwide. The predictive value of some blood inflammatory composite markers in OC has been extensively reported. They can be used for early detection and differential diagnosis of OC and can be used for predicting survival, treatment response, and recurrence in the affected patients. Here, we reviewed the predictive values of composite inflammatory markers based on complete blood count, namely neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio, and systemic inflammation index and markers based on blood protein, namely C-reactive protein-to-albumin ratio and prognostic nutritional index in OC, with a focus on NLR and PLR. We referred to the clinical studies on these six markers, reviewed the patient population, and summarized the marker cut-off values, significance, and limitations of these studies. All these studies were retrospective and most of them were single-center clinical studies with small sample sizes. We found that the cut-off values of these markers have not been unified, and methods used to determine these values varied among studies. The predictive value of these markers on survival was mainly reflected in the postoperative patients of multiple subtypes of ovarian cancer including epithelial OC, high-grade serous ovarian carcinoma, and ovarian clear cell carcinoma. We focused on NLR and PLR and calculated their pooled hazard ratios. NLR and PLR were reliable in predicting overall and progression-free survivals in patients with OC. Therefore, it is necessary to adjust important confounding factors and conduct a long-term follow-up prospective cohort study to further clarify the cut-off values of NLR and PLR and their clinical applications. |
| first_indexed | 2024-04-10T15:41:36Z |
| format | Article |
| id | doaj.art-0276c3557684467da84661b92923c60c |
| institution | Directory Open Access Journal |
| issn | 1757-2215 |
| language | English |
| last_indexed | 2024-04-10T15:41:36Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj.art-0276c3557684467da84661b92923c60c2023-02-12T12:19:36ZengBMCJournal of Ovarian Research1757-22152023-02-0116111310.1186/s13048-023-01116-2Independent predictive value of blood inflammatory composite markers in ovarian cancer: recent clinical evidence and perspective focusing on NLR and PLRChuan-long Zhang0Xiao-chen Jiang1Yi Li2Xue Pan3Meng-qi Gao4Yan Chen5Bo Pang6Guang’anmen Hospital, China Academy of Chinese Medical SciencesGuang’anmen Hospital, China Academy of Chinese Medical SciencesGuang’anmen Hospital, China Academy of Chinese Medical SciencesGuang’anmen Hospital, China Academy of Chinese Medical SciencesWangjing Hospital, China Academy of Chinese Medical SciencesInternational Medical Department of Guang’anmen Hospital, China Academy of Chinese Medical SciencesInternational Medical Department of Guang’anmen Hospital, China Academy of Chinese Medical SciencesAbstract Ovarian cancer (OC) is one of the deadliest malignant tumors affecting women worldwide. The predictive value of some blood inflammatory composite markers in OC has been extensively reported. They can be used for early detection and differential diagnosis of OC and can be used for predicting survival, treatment response, and recurrence in the affected patients. Here, we reviewed the predictive values of composite inflammatory markers based on complete blood count, namely neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio, and systemic inflammation index and markers based on blood protein, namely C-reactive protein-to-albumin ratio and prognostic nutritional index in OC, with a focus on NLR and PLR. We referred to the clinical studies on these six markers, reviewed the patient population, and summarized the marker cut-off values, significance, and limitations of these studies. All these studies were retrospective and most of them were single-center clinical studies with small sample sizes. We found that the cut-off values of these markers have not been unified, and methods used to determine these values varied among studies. The predictive value of these markers on survival was mainly reflected in the postoperative patients of multiple subtypes of ovarian cancer including epithelial OC, high-grade serous ovarian carcinoma, and ovarian clear cell carcinoma. We focused on NLR and PLR and calculated their pooled hazard ratios. NLR and PLR were reliable in predicting overall and progression-free survivals in patients with OC. Therefore, it is necessary to adjust important confounding factors and conduct a long-term follow-up prospective cohort study to further clarify the cut-off values of NLR and PLR and their clinical applications.https://doi.org/10.1186/s13048-023-01116-2Ovarian cancerComposite inflammatory markersPredictive valueClinical evidenceNLRPLR |
| spellingShingle | Chuan-long Zhang Xiao-chen Jiang Yi Li Xue Pan Meng-qi Gao Yan Chen Bo Pang Independent predictive value of blood inflammatory composite markers in ovarian cancer: recent clinical evidence and perspective focusing on NLR and PLR Journal of Ovarian Research Ovarian cancer Composite inflammatory markers Predictive value Clinical evidence NLR PLR |
| title | Independent predictive value of blood inflammatory composite markers in ovarian cancer: recent clinical evidence and perspective focusing on NLR and PLR |
| title_full | Independent predictive value of blood inflammatory composite markers in ovarian cancer: recent clinical evidence and perspective focusing on NLR and PLR |
| title_fullStr | Independent predictive value of blood inflammatory composite markers in ovarian cancer: recent clinical evidence and perspective focusing on NLR and PLR |
| title_full_unstemmed | Independent predictive value of blood inflammatory composite markers in ovarian cancer: recent clinical evidence and perspective focusing on NLR and PLR |
| title_short | Independent predictive value of blood inflammatory composite markers in ovarian cancer: recent clinical evidence and perspective focusing on NLR and PLR |
| title_sort | independent predictive value of blood inflammatory composite markers in ovarian cancer recent clinical evidence and perspective focusing on nlr and plr |
| topic | Ovarian cancer Composite inflammatory markers Predictive value Clinical evidence NLR PLR |
| url | https://doi.org/10.1186/s13048-023-01116-2 |
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