SH2 Domain-Containing Phosphatase-SHP2 Attenuates Fibrotic Responses through Negative Regulation of Mitochondrial Metabolism in Lung Fibroblasts

SH2 Domain-Containing Phosphatase-SHP2 Attenuates Fibrotic Responses through Negative Regulation of Mitochondrial Metabolism in Lung Fibroblasts

Background: We have previously shown that SHP2 downregulation may predispose fibroblasts to differentiate into myofibroblasts and proposed a role for SHP2 downregulation in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Recent data have shown that SHP2 localizes to the mitochondrial interc...

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Bibliographic Details
Main Authors: Theodoros Karampitsakos, Apostolos Galaris, Ilianna Barbayianni, Giuseppe DeIuliis, Farida Ahangari, Fotis Sampsonas, Vasilina Sotiropoulou, Vassilis Aidinis, Anton M. Bennett, Jose D. Herazo-Maya, Nikolaos Xylourgidis, Petros Bakakos, Demosthenes Bouros, Naftali Kaminski, Argyrios Tzouvelekis
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Diagnostics
Subjects:
SHP2
mitochondrial metabolism
mammalian target of rapamycin complex-1
fibroblast
Online Access:https://www.mdpi.com/2075-4418/13/6/1166

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