Recent Advances in the Role of Natural Killer Cells in Acute Kidney Injury
Growing evidence is revealing a central role for natural killer (NK) cells, cytotoxic cells belonging to the broad family of innate lymphoid cells (ILCs), in acute and chronic forms of renal disease. NK cell effector functions include both the recognition and elimination of virus-infected and tumor...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.01484/full |
| _version_ | 1818577059238117376 |
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| author | Claudia Cantoni Claudia Cantoni Simona Granata Maurizio Bruschi Grazia Maria Spaggiari Giovanni Candiano Gianluigi Zaza |
| author_facet | Claudia Cantoni Claudia Cantoni Simona Granata Maurizio Bruschi Grazia Maria Spaggiari Giovanni Candiano Gianluigi Zaza |
| author_sort | Claudia Cantoni |
| collection | DOAJ |
| description | Growing evidence is revealing a central role for natural killer (NK) cells, cytotoxic cells belonging to the broad family of innate lymphoid cells (ILCs), in acute and chronic forms of renal disease. NK cell effector functions include both the recognition and elimination of virus-infected and tumor cells and the capability of sensing pathogens through Toll-like receptor (TLR) engagement. Notably, they also display immune regulatory properties, exerted thanks to their ability to secrete cytokines/chemokines and to establish interactions with different innate and adaptive immune cells. Therefore, because of their multiple functions, NK cells may have a major pathogenic role in acute kidney injury (AKI), and a better understanding of the molecular mechanisms driving NK cell activation in AKI and their downstream interactions with intrinsic renal cells and infiltrating immune cells could help to identify new potential biomarkers and to select clinically valuable novel therapeutic targets. In this review, we discuss the current literature regarding the potential involvement of NK cells in AKI. |
| first_indexed | 2024-12-16T06:23:53Z |
| format | Article |
| id | doaj.art-0279c0eeff98493b90851e81ce4c8a32 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-16T06:23:53Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-0279c0eeff98493b90851e81ce4c8a322022-12-21T22:41:03ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-08-011110.3389/fimmu.2020.01484552749Recent Advances in the Role of Natural Killer Cells in Acute Kidney InjuryClaudia Cantoni0Claudia Cantoni1Simona Granata2Maurizio Bruschi3Grazia Maria Spaggiari4Giovanni Candiano5Gianluigi Zaza6Laboratory of Clinical and Experimental Immunology, Integrated Department of Services and Laboratories, IRCCS Istituto Giannina Gaslini, Genoa, ItalyDepartment of Experimental Medicine (DIMES) and Center of Excellence for Biomedical Research (CEBR), University of Genoa, Genoa, ItalyRenal Unit, Department of Medicine, University-Hospital of Verona, Verona, ItalyLaboratory of Molecular Nephrology, IRCCS Istituto Giannina Gaslini, Genoa, ItalyDepartment of Experimental Medicine (DIMES) and Center of Excellence for Biomedical Research (CEBR), University of Genoa, Genoa, ItalyLaboratory of Molecular Nephrology, IRCCS Istituto Giannina Gaslini, Genoa, ItalyRenal Unit, Department of Medicine, University-Hospital of Verona, Verona, ItalyGrowing evidence is revealing a central role for natural killer (NK) cells, cytotoxic cells belonging to the broad family of innate lymphoid cells (ILCs), in acute and chronic forms of renal disease. NK cell effector functions include both the recognition and elimination of virus-infected and tumor cells and the capability of sensing pathogens through Toll-like receptor (TLR) engagement. Notably, they also display immune regulatory properties, exerted thanks to their ability to secrete cytokines/chemokines and to establish interactions with different innate and adaptive immune cells. Therefore, because of their multiple functions, NK cells may have a major pathogenic role in acute kidney injury (AKI), and a better understanding of the molecular mechanisms driving NK cell activation in AKI and their downstream interactions with intrinsic renal cells and infiltrating immune cells could help to identify new potential biomarkers and to select clinically valuable novel therapeutic targets. In this review, we discuss the current literature regarding the potential involvement of NK cells in AKI.https://www.frontiersin.org/article/10.3389/fimmu.2020.01484/fullinflammationnatural killer (NK) cellstubular epithelial cellsacute kidney injuryinnate immunity |
| spellingShingle | Claudia Cantoni Claudia Cantoni Simona Granata Maurizio Bruschi Grazia Maria Spaggiari Giovanni Candiano Gianluigi Zaza Recent Advances in the Role of Natural Killer Cells in Acute Kidney Injury Frontiers in Immunology inflammation natural killer (NK) cells tubular epithelial cells acute kidney injury innate immunity |
| title | Recent Advances in the Role of Natural Killer Cells in Acute Kidney Injury |
| title_full | Recent Advances in the Role of Natural Killer Cells in Acute Kidney Injury |
| title_fullStr | Recent Advances in the Role of Natural Killer Cells in Acute Kidney Injury |
| title_full_unstemmed | Recent Advances in the Role of Natural Killer Cells in Acute Kidney Injury |
| title_short | Recent Advances in the Role of Natural Killer Cells in Acute Kidney Injury |
| title_sort | recent advances in the role of natural killer cells in acute kidney injury |
| topic | inflammation natural killer (NK) cells tubular epithelial cells acute kidney injury innate immunity |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.01484/full |
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